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Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population
Joint Authors
Lujambio, Inés
Sottolano, Mariana
Luzardo, Leonella
Robaina, Sebastián
Krul, Nadia
Thijs, Lutgarde
Carusso, Florencia
da Rosa, Alicia
Ríos, Ana Carina
Olascoaga, Alicia
Garau, Mariela
Gadola, Liliana
Noboa, Oscar
Staessen, Jan A.
Boggia, José
Source
International Journal of Nephrology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Estimation of glomerular filtration rate (eGFR) from biomarkers has evolved and multiple equations are available to estimate renal function at bedside.
Methods.
In a random sample of 119 Uruguayans (54.5% women; 56.2 years (mean)), we used Bland and Altman’s method and Cohen’s kappa statistic to assess concordance on a continuous or categorical (eGFR < 60 versus ≥60 mL/min/1.73 m2) scale between eGFRcys (reference) and eGFR derived from serum creatinine according to the Modification of Diet in Renal Disease (eGFRmdrd) or the Chronic Kidney Disease Epidemiology Collaboration equations (eGFRepi) or from both serum cystatin C and creatinine (eGFRmix).
Results.
In all participants, eGFRmdrd, eGFRepi, and eGFRmix were, respectively, 9.7, 11.5, and 5.6 mL/min/1.73 m2 higher ( P < 0.0001 ) than eGFRcys.
The prevalence of eGFR <60 mL/min/1.73 m2 was the highest for eGFRcys (21.8%), intermediate for eGFRmix (11.8%), and the lowest for eGFRmdrd (5.9%) and eGFRepi (3.4%).
Using eGFRcys as reference, we found only fair agreement with the equations based on creatinine (Cohen’s kappa statistic 0.15 to 0.23).
Conclusion.
Using different equations we reached clinically significant differences in the estimation of renal function.
eGFRcys provides lower estimates, resulting in higher prevalence of eGFR <60 mL/min/1.73 m2.
American Psychological Association (APA)
Lujambio, Inés& Sottolano, Mariana& Luzardo, Leonella& Robaina, Sebastián& Krul, Nadia& Thijs, Lutgarde…[et al.]. 2014. Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036755
Modern Language Association (MLA)
Lujambio, Inés…[et al.]. Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population. International Journal of Nephrology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036755
American Medical Association (AMA)
Lujambio, Inés& Sottolano, Mariana& Luzardo, Leonella& Robaina, Sebastián& Krul, Nadia& Thijs, Lutgarde…[et al.]. Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036755