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The Effect of Topical Application of Royal Jelly on Chemoradiotherapy-Induced Mucositis in Head and Neck Cancer: A Preliminary Study
Joint Authors
Kogashiwa, Yasunao
Moro, Yorihisa
Kohno, Naoyuki
Yamauchi, Kohichi
Source
International Journal of Otolaryngology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
One of the common side effects experienced by head and neck cancer patients on chemoradiotherapy is mucositis.
Severe mucositis may be controllable by limiting cancer therapy, but it has resulted in decreasing the completion rate of chemoradiotherapy.
The efficacy of royal jelly (RJ) as prophylaxis against chemoradiotherapy-induced mucositis was evaluated through clinical scoring of oral and pharyngeal mucositis.
Methods.
In this randomized, single-blind (physician-blind), clinical trial, 13 patients with head and neck cancer requiring chemoradiation were randomly assigned to two groups.
Seven patients assigned to the study group received RJ, and 6 patients were assigned to the control group.
RJ group patients took RJ three times per day during treatment.
The patients in both groups were evaluated twice a week for the development of mucositis using Common Terminology Criteria for Adverse Events version 3.0.
Results.
A significant reduction in mucositis was seen among RJ-treated patients compared with controls ( P < 0.001 ).
Conclusion.
This study demonstrated that prophylactic use of RJ was effective in reducing mucositis induced by chemoradiotherapy in head and neck cancer patients.
However, further studies are needed because of the small sample size and the absence of double blinding.
American Psychological Association (APA)
Yamauchi, Kohichi& Kogashiwa, Yasunao& Moro, Yorihisa& Kohno, Naoyuki. 2014. The Effect of Topical Application of Royal Jelly on Chemoradiotherapy-Induced Mucositis in Head and Neck Cancer: A Preliminary Study. International Journal of Otolaryngology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1036770
Modern Language Association (MLA)
Yamauchi, Kohichi…[et al.]. The Effect of Topical Application of Royal Jelly on Chemoradiotherapy-Induced Mucositis in Head and Neck Cancer: A Preliminary Study. International Journal of Otolaryngology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1036770
American Medical Association (AMA)
Yamauchi, Kohichi& Kogashiwa, Yasunao& Moro, Yorihisa& Kohno, Naoyuki. The Effect of Topical Application of Royal Jelly on Chemoradiotherapy-Induced Mucositis in Head and Neck Cancer: A Preliminary Study. International Journal of Otolaryngology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1036770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036770