Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles
Joint Authors
Douplik, Alexander
Assadi, Homa
Karshafian, Raffi
Source
International Journal of Photoenergy
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In imaging, contrast agents are utilized to enhance sensitivity and specificity of diagnostic modalities.
In ultrasound imaging, microbubbles (MBs)—a gas-core shell-encapsulated agent—are used clinically as contrast agents.
The working hypothesis of this study is that microbubbles can be employed as an intravascular contrast agent in optical imaging systems.
In this work, the interaction of light and microbubbles in a turbid medium (intralipid) was investigated, particularly, the effect of MBs on the reduced scattering and absorption coefficients.
Diffuse reflectance (DR) and total transmittance (TT) measurements of highly scattering intralipid suspension (0.5–5%) were measured using spectroscopic integrating sphere system in the absence and presence of Definity microbubbles.
The optical properties were computed using the inverse adding doubling (IAD) software.
The presence of microbubbles increased DR and decreased TT of intralipid phantoms.
In the presence of MBs (0.5% volume concentration), the reflectance of the intralipid phantom increased from 35% to 100%.
The reduced scattering coefficient increased significantly (30%) indicating potential use of MBs as optical contrast agents in light based modalities.
American Psychological Association (APA)
Assadi, Homa& Karshafian, Raffi& Douplik, Alexander. 2014. Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles. International Journal of Photoenergy،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036938
Modern Language Association (MLA)
Assadi, Homa…[et al.]. Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles. International Journal of Photoenergy No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036938
American Medical Association (AMA)
Assadi, Homa& Karshafian, Raffi& Douplik, Alexander. Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles. International Journal of Photoenergy. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036938