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Effect of UV Irradiation and Temperature on Free Radical Properties in Dehydrocholic and Ursodeoxycholic Acids: An EPR Study
Joint Authors
Ramos, Paweł
Pilawa, Barbara
Dołowy, Małgorzata
Source
International Journal of Photoenergy
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The effect of UV irradiation and temperature on the formation and properties of free radicals in two pharmaceutical important bile acids, such as dehydrocholic (DH) and ursodeoxycholic acids (UDC), was examined.
Electron paramagnetic resonance (EPR) spectroscopy was applied to determine the paramagnetic character of UV irradiated and thermally sterilized drugs.
Thermal and UV irradiation sterilizations of both compounds were carried out at different conditions according to pharmaceutical norms.
The performed EPR measurements of UV irradiated and thermally sterilized DH and UDC samples proved the existence of the complex free radical systems in examined bile acids.
Significant influence of UV irradiation in comparison with applied thermal sterilization on free radical concentrations in DH and UDC samples was observed.
The results pointed out that thermal method is most suitable for bile acid sterilization.
Therefore, this kind of sterilization should be applied in practice.
American Psychological Association (APA)
Dołowy, Małgorzata& Ramos, Paweł& Pilawa, Barbara. 2014. Effect of UV Irradiation and Temperature on Free Radical Properties in Dehydrocholic and Ursodeoxycholic Acids: An EPR Study. International Journal of Photoenergy،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1037469
Modern Language Association (MLA)
Dołowy, Małgorzata…[et al.]. Effect of UV Irradiation and Temperature on Free Radical Properties in Dehydrocholic and Ursodeoxycholic Acids: An EPR Study. International Journal of Photoenergy No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1037469
American Medical Association (AMA)
Dołowy, Małgorzata& Ramos, Paweł& Pilawa, Barbara. Effect of UV Irradiation and Temperature on Free Radical Properties in Dehydrocholic and Ursodeoxycholic Acids: An EPR Study. International Journal of Photoenergy. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1037469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1037469