Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy
Joint Authors
Thornton, Kimberly M.
Dai, Hongying
Septer, Seth
Petrikin, Joshua E.
Source
International Journal of Pediatrics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
This retrospective cohort study evaluated the effects of whole body therapeutic hypothermia (WBTH) on gastrointestinal (GI) morbidity and feeding tolerance in infants with moderate-to-severe hypoxic ischemic encephalopathy (HIE).
Study Design.
Infants ≥ 35 weeks gestational age and ≥1800 grams birth weight with moderate-to-severe HIE treated from 2000 to 2012 were compared.
68 patients had documented strictly defined criteria for WBTH: 32 historical control patients did not receive WBTH (non-WBTH) and 36 cohort patients received WBTH.
Result.
More of the non-WBTH group infants never initiated enteral feeds (28% versus 6%; P = 0.02 ), never reached full enteral feeds (38% versus 6%, P = 0.002 ), and never reached full oral feeds (56% versus 19%, P = 0.002 ).
Survival analyses demonstrated that the WBTH group reached full enteral feeds (median time: 11 versus 9 days; P = 0.02 ) and full oral feeds (median time: 19 versus 10 days; P = 0.01 ) sooner.
The non-WBTH group had higher combined outcomes of death and gastric tube placement (47% versus 11%; P = 0.001 ) and death and gavage feeds at discharge (44% versus 11%; P = 0.005 ).
Conclusion.
WBTH may have beneficial effects on GI morbidity and feeding tolerance for infants with moderate-to-severe HIE.
American Psychological Association (APA)
Thornton, Kimberly M.& Dai, Hongying& Septer, Seth& Petrikin, Joshua E.. 2014. Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy. International Journal of Pediatrics،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1037487
Modern Language Association (MLA)
Thornton, Kimberly M.…[et al.]. Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy. International Journal of Pediatrics No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1037487
American Medical Association (AMA)
Thornton, Kimberly M.& Dai, Hongying& Septer, Seth& Petrikin, Joshua E.. Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy. International Journal of Pediatrics. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1037487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1037487