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A Novel Algorithm in the Management of Hypoglycemia in Newborns
Joint Authors
Naveen, Swapna
Rosy, Chikati
Kandraju, Hemasree
Sharma, Deepak
Oleti, Tejopratap
Murki, Srinivas
Source
International Journal of Pediatrics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Study Objective.
To evaluate the safety of a new protocol in comparison to the standard protocol for managing hypoglycemia in neonates.
Methods.
Open label RCT-pilot study.
Neonates admitted to NICU with hypoglycemia and requiring intravenous fluids were included.
Fifty-seven eligible neonates were randomly allocated to either intervention group (starting fluids with 10% dextrose and increments of 1.5%) or standard protocol group (GIR of 6 mg/kg/min with increments of 2 mg/kg/min) till control of hypoglycemia.
Primary outcome of the study was to know proportion of infants with subsequent hypoglycemia and hyperglycemia after enrolment.
Results.
The initial GIR (6 ± 0 mg/kg/min versus 4.8 ± 1.4 mg/kg/min, P < 0.001), the mean maximum GIR (6.7 ± 1.6 mg/kg/min versus 5.6 ± 2 mg/kg/min, P = 0.03), the maximum concentration of glucose infused (13.8 ± 2.9% versus 10.9 ± 1.9%, P < 0.001), and the total amount of glucose infused were significantly lower in the intervention group.
The mean maximum blood sugar was significantly higher (129 ± 57 mg/dL versus 87 ± 30 mg/dL, P = 0.001) and there was a trend towards high proportion of infants with Hyperglycemia in the standard protocol group (n = 10, 39% versus n = 5, 16%, P = 0.07).
The median difference between the highest and the lowest recorded sugar for any infant was significantly higher in the standard protocol group (median 93 mg/dL, IQR 52 to 147 mg/dL versus median 50 mg/dL, IQR 38 to 62.5 mg/dL, P = 0.03).
Conclusion.
A new and novel algorithm in the management of hypoglycemia in neonates is as safe as the standard protocol and requires further testing before routine implementation.
American Psychological Association (APA)
Naveen, Swapna& Rosy, Chikati& Kandraju, Hemasree& Sharma, Deepak& Oleti, Tejopratap& Murki, Srinivas. 2014. A Novel Algorithm in the Management of Hypoglycemia in Newborns. International Journal of Pediatrics،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1037491
Modern Language Association (MLA)
Naveen, Swapna…[et al.]. A Novel Algorithm in the Management of Hypoglycemia in Newborns. International Journal of Pediatrics No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1037491
American Medical Association (AMA)
Naveen, Swapna& Rosy, Chikati& Kandraju, Hemasree& Sharma, Deepak& Oleti, Tejopratap& Murki, Srinivas. A Novel Algorithm in the Management of Hypoglycemia in Newborns. International Journal of Pediatrics. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1037491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1037491