Enhancement of VEGF on Axial Vascularization of Nano-HACollagenPLA Composites: A Histomorphometric Study on Rabbits
Joint Authors
Qiu, Guixing
Wang, Hai
Cui, Fuzhai
Weng, Xisheng
Zhang, Baozhong
Yang, Bo
Lian, Xiaojie
Wu, Zhihong
Chang, Xiao
Source
International Journal of Polymer Science
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this study was to investigate whether the nanohydroxyapatite/collagen/poly(L-lactic acid) (nHAC/PLA) composite is suitable to be compounded with VEGF to enhance the axial vascularization in vivo.
Thirty rabbits were divided into 2 groups of 15 animals each.
In control group, a nHAC/PLA scaffold slice was vascularized axially by an inserted ligated femoral arteriovenous (AV) bundle in the animal.
In experimental group, a slice compounded with VEGF gel was applied.
The rabbits were sacrificed at 2 weeks, 6 weeks, and 10 weeks after surgery; the specimens of scaffold slices underwent histomorphometric examination; analysis of the microvessel density (MVD) of both groups was done.
The combination with VEGF (Group B) did not enhance the vascularization in early phase (2 and 6 weeks, P > 0.05 ) but worked in later phase (10 weeks, P < 0.05 ).
The data of the experiment demonstrated the suitability of the nHAC/PLA composite as carrier for the growth factor VEGF, enabling its sustained release in bioactive form with enough binding efficacy.
American Psychological Association (APA)
Chang, Xiao& Wang, Hai& Wu, Zhihong& Lian, Xiaojie& Cui, Fuzhai& Weng, Xisheng…[et al.]. 2014. Enhancement of VEGF on Axial Vascularization of Nano-HACollagenPLA Composites: A Histomorphometric Study on Rabbits. International Journal of Polymer Science،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1037502
Modern Language Association (MLA)
Chang, Xiao…[et al.]. Enhancement of VEGF on Axial Vascularization of Nano-HACollagenPLA Composites: A Histomorphometric Study on Rabbits. International Journal of Polymer Science No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1037502
American Medical Association (AMA)
Chang, Xiao& Wang, Hai& Wu, Zhihong& Lian, Xiaojie& Cui, Fuzhai& Weng, Xisheng…[et al.]. Enhancement of VEGF on Axial Vascularization of Nano-HACollagenPLA Composites: A Histomorphometric Study on Rabbits. International Journal of Polymer Science. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1037502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1037502