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Surface-Coated Polylactide Fiber Meshes as Tissue Engineering Matrices with Enhanced Cell Integration Properties
Joint Authors
Wyrwa, Ralf
Rebl, Henrike
Bergemann, Claudia
Schlosser, Michael
Walschus, Uwe
Lucke, Silke
Weltmann, Klaus-Dieter
Nebe, J. Barbara
Finke, Birgit
Schnabelrauch, Matthias
Source
International Journal of Polymer Science
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Poly(L-lactide-co-D/L-lactide)-based fiber meshes resembling structural features of the native extracellular matrix have been prepared by electrospinning.
Subsequent coating of the electrospun fibers with an ultrathin plasma-polymerized allylamine (PPAAm) layer after appropriate preactivation with continuous O2/Ar plasma changed the hydrophobic nature of the polylactide surface into a hydrophilic polymer network and provided positively charged amino groups on the fiber surface able to interact with negatively charged pericellular matrix components.
In vitro cell experiments using different human cell types (epithelial origin: gingiva and uroepithelium; bone cells: osteoblasts) revealed that the PPAAm-activated surfaces promoted the occupancy of the meshes by cells accompanied by improved initial cell spreading.
This nanolayer is stable in its cell adhesive characteristics also after γ-sterilization.
An in vivo study in a rat intramuscular implantation model demonstrated that the local inflammatory tissue response did not differ between PPAAm-coated and untreated polylactide meshes.
American Psychological Association (APA)
Schnabelrauch, Matthias& Wyrwa, Ralf& Rebl, Henrike& Bergemann, Claudia& Finke, Birgit& Schlosser, Michael…[et al.]. 2014. Surface-Coated Polylactide Fiber Meshes as Tissue Engineering Matrices with Enhanced Cell Integration Properties. International Journal of Polymer Science،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1037521
Modern Language Association (MLA)
Schnabelrauch, Matthias…[et al.]. Surface-Coated Polylactide Fiber Meshes as Tissue Engineering Matrices with Enhanced Cell Integration Properties. International Journal of Polymer Science No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1037521
American Medical Association (AMA)
Schnabelrauch, Matthias& Wyrwa, Ralf& Rebl, Henrike& Bergemann, Claudia& Finke, Birgit& Schlosser, Michael…[et al.]. Surface-Coated Polylactide Fiber Meshes as Tissue Engineering Matrices with Enhanced Cell Integration Properties. International Journal of Polymer Science. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1037521
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1037521