Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems
Joint Authors
Massoudi, Abdolhossien
Adeli, Mohsen
Khosravi far, Leila
Source
International Journal of Polymer Science
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Pseudopolyrotaxanes (PPR) consisting of α-cyclodextrin rings and polyethylene glycol axes with end thymine groups have been synthesized and characterized successfully.
Fluorescein (Fl) as a model drug was conjugated to the hydroxyl functional groups of cyclodextrin rings of PPR via ester bonds and PPR-Fl as the primary drug delivery system was obtained.
Finally PPR-Fl was capped by hydrogen bonds between end thymine groups and a suitable complementary molecule such as polycitric acid, citric acid, or adenine.
The aim of this work was to control the release of the fluorescein-cyclodextrin (Fl-CD) conjugates, as the secondary drug delivery systems, from PPR-Fl by controlling the noncovalent interactions between stoppers and thymine end groups.
It was found that the rate of release of the Fl-CD from PPR-Fl could be controlled by pH and the ratio of citric acid or adenine to the PPR-Fl.
American Psychological Association (APA)
Massoudi, Abdolhossien& Adeli, Mohsen& Khosravi far, Leila. 2014. Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems. International Journal of Polymer Science،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1037581
Modern Language Association (MLA)
Massoudi, Abdolhossien…[et al.]. Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems. International Journal of Polymer Science No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1037581
American Medical Association (AMA)
Massoudi, Abdolhossien& Adeli, Mohsen& Khosravi far, Leila. Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems. International Journal of Polymer Science. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1037581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1037581