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Comparison of IVF Outcomes between Minimal Stimulation and High-Dose Stimulation for Patients with Poor Ovarian Reserve
Joint Authors
Lazer, Tal
Dar, Shir
Shlush, Ekaterina
Al Kudmani, Basheer S.
Quach, Kevin
Sojecki, Agata
Glass, Karen
Sharma, Prati
Baratz, Ari
Librach, Clifford L.
Source
International Journal of Reproductive Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We examined whether treatment with minimum-dose stimulation (MS) protocol enhances clinical pregnancy rates compared to high-dose stimulation (HS) protocol.
A retrospective cohort study was performed comparing IVF and pregnancy outcomes between MS and HS gonadotropin-antagonist protocol for patients with poor ovarian reserve (POR).
Inclusion criteria included patients with an anti-Müllerian hormone (AMH) ≤8 pmol/L and/or antral follicle count (AFC) ≤5 on days 2-3 of the cycle.
Patients from 2008 exclusively had a HS protocol treatment, while patients in 2010 had treatment with a MS protocol exclusively.
The MS protocol involved letrozole at 2.5 mg over 5 days, starting from day 2, overlapping with gonadotropins, starting from the third day of letrozole at 150 units daily.
GnRH antagonist was introduced once one or more follicles reached 14 mm or larger.
The HS group received gonadotropins (≥300 IU/day) throughout their antagonist cycle.
Clinical pregnancy rate was significantly higher in the MS protocol compared to the HS protocol ( P = 0.007 ).
Furthermore, the live birth rate was significantly higher in the MS group compare to the HS group ( P = 0.034 ).
In conclusion, the MS IVF protocol is less expensive (lower gonadotropin dosage) and resulted in a higher clinical pregnancy rate and live birth rate than a HS protocol for poor responders.
American Psychological Association (APA)
Lazer, Tal& Dar, Shir& Shlush, Ekaterina& Al Kudmani, Basheer S.& Quach, Kevin& Sojecki, Agata…[et al.]. 2014. Comparison of IVF Outcomes between Minimal Stimulation and High-Dose Stimulation for Patients with Poor Ovarian Reserve. International Journal of Reproductive Medicine،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1037675
Modern Language Association (MLA)
Lazer, Tal…[et al.]. Comparison of IVF Outcomes between Minimal Stimulation and High-Dose Stimulation for Patients with Poor Ovarian Reserve. International Journal of Reproductive Medicine No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1037675
American Medical Association (AMA)
Lazer, Tal& Dar, Shir& Shlush, Ekaterina& Al Kudmani, Basheer S.& Quach, Kevin& Sojecki, Agata…[et al.]. Comparison of IVF Outcomes between Minimal Stimulation and High-Dose Stimulation for Patients with Poor Ovarian Reserve. International Journal of Reproductive Medicine. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1037675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1037675