Purpurogallin, a Natural Phenol, Attenuates High-Mobility Group Box 1 in Subarachnoid Hemorrhage Induced Vasospasm in a Rat Model
Joint Authors
Lin, Chih-Lung
Kwan, Aij-Lie
Chang, Chih-Zen
Wu, Shu-Chuan
Source
International Journal of Vascular Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
High-mobility group box 1 (HMGB1) was shown to be an important extracellular mediator involved in vascular inflammation of animals following subarachnoid hemorrhage (SAH).
This study is of interest to examine the efficacy of purpurogallin, a natural phenol, on the alternation of cytokines and HMGB1 in a SAH model.
A rodent double hemorrhage SAH model was employed.
Basilar arteries (BAs) were harvested to examine HMGB1 mRNA and protein expression (Western blot).
CSF samples were to examine IL-1β, IL-6, IL-8, and TNF-α (rt-PCR).
Deformed endothelial wall, tortuous elastic lamina, and necrotic smooth muscle were observed in the vessels of SAH groups but were absent in the purpurogallin group.
IL-1β, IL-6, and TNF-α in the SAH only and SAH plus vehicle groups were significantly elevated (P<0.01).
Purpurgallin dose-dependently reduced HMGB1 protein expression.
Likewise, high dose purpurogallin reduced TNF-α and HMGB1 mRNA levels.
In conclusion, purpurogallin exerts its neuroinflammation effect through the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression.
This study supports purpurogallin could attenuate both proinflammatory cytokines and late-onset inflammasome in SAH induced vasospasm.
American Psychological Association (APA)
Chang, Chih-Zen& Lin, Chih-Lung& Wu, Shu-Chuan& Kwan, Aij-Lie. 2014. Purpurogallin, a Natural Phenol, Attenuates High-Mobility Group Box 1 in Subarachnoid Hemorrhage Induced Vasospasm in a Rat Model. International Journal of Vascular Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1037690
Modern Language Association (MLA)
Chang, Chih-Zen…[et al.]. Purpurogallin, a Natural Phenol, Attenuates High-Mobility Group Box 1 in Subarachnoid Hemorrhage Induced Vasospasm in a Rat Model. International Journal of Vascular Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1037690
American Medical Association (AMA)
Chang, Chih-Zen& Lin, Chih-Lung& Wu, Shu-Chuan& Kwan, Aij-Lie. Purpurogallin, a Natural Phenol, Attenuates High-Mobility Group Box 1 in Subarachnoid Hemorrhage Induced Vasospasm in a Rat Model. International Journal of Vascular Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1037690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1037690