Mass transfer coefficient study for release of naproxen from activated carbon for drug delivery application

Abstract EN

Activated carbon is a porous material that has a great character to be used for drug delivery system as a carrier.

It is agreed that drug carriers maintain the concentration of drugs within the required range for a long period and undetermined toxicity resulting from the use of overdoses.

They have the ability to direct the drug to the affected area, immunity, biophysics, and drug efficacy.

Activated carbon was used at two different particle sizes (0.6μm size with surface area 544.4704 m2/g and 11.042 nm size with surface area 985.6013m2/g ) and Naproxen was used as a drug model.

This research studied the effect of several parameters, including particle size (11.042 nm and 0.6μm), weight of drug to carrier weight ratio (0.5, 1 and 1.5) on loading efficiency, and temperature (35, 37 and 39 ºC), time (1, 3 and 5 hr), pH of the solution (1.5 and 6.5) on mass transfer coefficient in release drug.

The result of experiments showed that maximum loading efficiency can be obtained when the particle size of activated carbon was in Nano-size and the ratio of drug weight to AC weight was 1.5.

The release process was studied by studying the mass transfer coefficient, the highest value of the mass transfer coefficient was obtained at the beginning of the unloading time, at temperature 37 ºC and solution in pH 6.5.