Validated Method for the Determination of Piroxicam by Capillary Zone Electrophoresis and Its Application to Tablets
Joint Authors
Dal, Arın Gül
Oktayer, Zeynep
Doğrukol-Ak, Dilek
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Simple and rapid capillary zone electrophoretic method was developed and validated in this study for the determination ofpiroxicam in tablets.
The separation of piroxicam was conducted in a fused-silica capillary by using 10 mM borate buffer (pH 9.0) containing 10% (v/v) methanol as background electrolyte.
The optimum conditions determined were 25 kV for separation voltage and 1 s for injection time.
Analysis was carried out with UV detection at 204 nm.
Naproxen sodium was used as an internal standard.
The method was linear over the range of 0.23–28.79 µg/mL.
The accuracy and precision were found to be satisfied within the acceptable limits (<2%).
The LOD and LOQ were found to be 0.07 and 0.19 µg/mL, respectively.
The method described here was applied to tablet dosage forms and the content of a tablet was found in the limits of USP-24 suggestions.
To compare the results of capillary electrophoretic method, UV spectrophotometric method was developed and the difference between two methods was found to be insignificant.
The capillary zone electrophoretic method developed in this study is rapid, simple, and suitable for routine analysis of piroxicam in pharmaceutical tablets.
American Psychological Association (APA)
Dal, Arın Gül& Oktayer, Zeynep& Doğrukol-Ak, Dilek. 2014. Validated Method for the Determination of Piroxicam by Capillary Zone Electrophoresis and Its Application to Tablets. Journal of Analytical Methods in Chemistry،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1039821
Modern Language Association (MLA)
Dal, Arın Gül…[et al.]. Validated Method for the Determination of Piroxicam by Capillary Zone Electrophoresis and Its Application to Tablets. Journal of Analytical Methods in Chemistry No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1039821
American Medical Association (AMA)
Dal, Arın Gül& Oktayer, Zeynep& Doğrukol-Ak, Dilek. Validated Method for the Determination of Piroxicam by Capillary Zone Electrophoresis and Its Application to Tablets. Journal of Analytical Methods in Chemistry. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1039821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1039821