Identification of the Related Substances in Ampicillin Capsule by Rapid Resolution Liquid Chromatography Coupled with Electrospray Ionization Tandem Mass Spectrometry
Joint Authors
Zhang, Lei
Liu, Yang
Liang, Miao
Dong, Honghuan
Lv, Beiran
Yang, Wenning
Luo, Zhiqiang
Tang, Mingmin
Cheng, Xian-Long
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-04
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Rapid Resolution Liquid Chromatography coupled with Electrospray Ionization Tandem Mass Spectrometry (RRLC-ESI-MSn) was used to separate and identify related substances in ampicillin capsule.
The fragmentation behaviors of related substances were used to identify their chemical structures.
Finally, a total of 13 related substances in ampicillin capsule were identified, including four identified components for the first time and three groups of isomers on the basis of the exact mass, fragmentation behaviors, retention time, and chemical structures in the literature.
This study avoided time-consuming and complex chemosynthesis of related substances of ampicillin and the results could be useful for the quality control of ampicillin capsule to guarantee its safety in clinic.
In the meantime, it provided a good example for the rapid identification of chemical structures of related substances of drugs.
American Psychological Association (APA)
Zhang, Lei& Cheng, Xian-Long& Liu, Yang& Liang, Miao& Dong, Honghuan& Lv, Beiran…[et al.]. 2014. Identification of the Related Substances in Ampicillin Capsule by Rapid Resolution Liquid Chromatography Coupled with Electrospray Ionization Tandem Mass Spectrometry. Journal of Analytical Methods in Chemistry،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1039822
Modern Language Association (MLA)
Zhang, Lei…[et al.]. Identification of the Related Substances in Ampicillin Capsule by Rapid Resolution Liquid Chromatography Coupled with Electrospray Ionization Tandem Mass Spectrometry. Journal of Analytical Methods in Chemistry No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1039822
American Medical Association (AMA)
Zhang, Lei& Cheng, Xian-Long& Liu, Yang& Liang, Miao& Dong, Honghuan& Lv, Beiran…[et al.]. Identification of the Related Substances in Ampicillin Capsule by Rapid Resolution Liquid Chromatography Coupled with Electrospray Ionization Tandem Mass Spectrometry. Journal of Analytical Methods in Chemistry. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1039822
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1039822
