Chitosan Hydrogels for Chondroitin Sulphate Controlled Release: An Analytical Characterization

Joint Authors

Bettini, Ruggero
Bianchera, Annalisa
Salomi, Enrico
Pezzanera, Matteo
Ruwet, Elisabeth
Elviri, Lisa

Source

Journal of Analytical Methods in Chemistry

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-12-31

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Chemistry

Abstract EN

This paper provides an analytical characterization of chitosan scaffolds obtained by freeze-gelation toward the uptake and the controlled release of chondroitin sulphate (CS), as cartilage repair agent, under different pH conditions.

Scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and liquid chromatography-UV spectrophotometry (LC-UV) techniques were exploited to obtain qualitative and quantitative descriptions of polymer and drug behaviour in the biomaterial.

As for morphology, SEM analysis allowed the evaluation of scaffold porosity in terms of pore size and distribution both at the surface (Feret diameter 58 ± 19 μm) and on the cross section (Feret diameter 106 ± 51 μm).

LC and ATR-FTIR evidenced a pH-dependent CS loading and release behaviour, strongly highlighting the role of electrostatic forces on chitosan/chondroitin sulphate interactions.

American Psychological Association (APA)

Bianchera, Annalisa& Salomi, Enrico& Pezzanera, Matteo& Ruwet, Elisabeth& Bettini, Ruggero& Elviri, Lisa. 2014. Chitosan Hydrogels for Chondroitin Sulphate Controlled Release: An Analytical Characterization. Journal of Analytical Methods in Chemistry،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1039840

Modern Language Association (MLA)

Bianchera, Annalisa…[et al.]. Chitosan Hydrogels for Chondroitin Sulphate Controlled Release: An Analytical Characterization. Journal of Analytical Methods in Chemistry No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1039840

American Medical Association (AMA)

Bianchera, Annalisa& Salomi, Enrico& Pezzanera, Matteo& Ruwet, Elisabeth& Bettini, Ruggero& Elviri, Lisa. Chitosan Hydrogels for Chondroitin Sulphate Controlled Release: An Analytical Characterization. Journal of Analytical Methods in Chemistry. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1039840

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1039840