Synthesis of 1,8-Naphthyridine Derivatives under Ultrasound Irradiation and Cytotoxic Activity against HepG2 Cell Lines
Joint Authors
Ahmed, N. S.
AlFooty, K. O.
Khalifah, S. S.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Novel pyrazole derivatives 3a,b, 5, 1,3,4-oxadiazole 6, 1,3,4-thiadiazole 8, and 1,2,4-triazole 9a–c incorporated into 1,8-naphthyridine have been synthesized using the versatile synthon 2-(2,7-dimethyl-1,8-naphthyridin-4-yloxy) acetohydrazide 1.
An improvement in rates and yields was observed when the reactions were carried out under ultrasonic irradiation compared with the classical synthesis.
The newly synthesized compounds were evaluated for HepG2 cell growth inhibition.
The results obtained revealed that the tested compounds possess inhibitory effect on the growth of HepG2 liver cancer cells.
The results were compared to doxorubicin (DOX) as a reference drug (IC50 : 0.04 μM).
Compounds 9b showed the highest inhibition activity against HepG2 cell line (IC50 : 0.048 μM) among all tested compounds.
American Psychological Association (APA)
Ahmed, N. S.& AlFooty, K. O.& Khalifah, S. S.. 2014. Synthesis of 1,8-Naphthyridine Derivatives under Ultrasound Irradiation and Cytotoxic Activity against HepG2 Cell Lines. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1039894
Modern Language Association (MLA)
Ahmed, N. S.…[et al.]. Synthesis of 1,8-Naphthyridine Derivatives under Ultrasound Irradiation and Cytotoxic Activity against HepG2 Cell Lines. Journal of Chemistry No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1039894
American Medical Association (AMA)
Ahmed, N. S.& AlFooty, K. O.& Khalifah, S. S.. Synthesis of 1,8-Naphthyridine Derivatives under Ultrasound Irradiation and Cytotoxic Activity against HepG2 Cell Lines. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1039894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1039894
