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Cardioprotective Activity of N ′ ′ , N ′ ′ ′ -Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats
Joint Authors
Sarangapani, M.
Tabassum, Salma
Thumma, Gouthami
Anreddy, Rama Narsimha Reddy
Kiran, G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study was aimed at evaluating the cardioprotective effect of novel synthetic N ′ ′ , N ′ ′ ′ -bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide derivative, by estimating the various biomarkers like creatine kinase-myoglobin (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and triglycerides (TG) in plasma and antioxidants like catalase, superoxide dismutase in heart tissue homogenate, and histopathological examination of heart tissues.
The results showed the significant ( P < 0.05 ) dose dependent decrease in elevated cardiotoxic biomarkers CK-MB, LDH, AST, and TG levels.
The histopathological studies of heart tissues showed mild degeneration of muscle bundles and less interstitial edematous changes.
The results showed the significant ( P < 0.05 ) dose dependent increase in antioxidant enzymes catalase and superoxide dismutase in heart tissue homogenates.
These observations enable us to conclude that N ′ ′ , N ′ ′ ′ -bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide has cardioprotective activity against doxorubicin induced cardiotoxicity.
American Psychological Association (APA)
Tabassum, Salma& Kiran, G.& Thumma, Gouthami& Sarangapani, M.& Anreddy, Rama Narsimha Reddy. 2014. Cardioprotective Activity of N ′ ′ , N ′ ′ ′ -Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1039927
Modern Language Association (MLA)
Tabassum, Salma…[et al.]. Cardioprotective Activity of N ′ ′ , N ′ ′ ′ -Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats. Journal of Chemistry No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1039927
American Medical Association (AMA)
Tabassum, Salma& Kiran, G.& Thumma, Gouthami& Sarangapani, M.& Anreddy, Rama Narsimha Reddy. Cardioprotective Activity of N ′ ′ , N ′ ′ ′ -Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1039927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1039927