Physicochemical, Spectral, and Biological Studies of Mn(II)‎, Cu(II)‎, Cd(II)‎, Zr(OH)‎ 2(IV)‎, and UO 2(VI)‎ Compounds with Ligand Containing Thiazolidin-4-one Moiety

Abstract EN

The Schiff base (I) upon reacting with mercaptoacetic acid in dry benzene undergoes cyclization and forms N-(2-carbamoylthienyl)-C-(3′-carboxy-2′-hydroxyphenyl)thiazolidin-4-one, LH3 (II).

A MeOH solution of II reacts with Mn(II), Cu(II), Cd(II), Zr(OH)2(IV), and UO2(VI) ions and forms the coordination compounds, [Mn(LH)(MeOH)2], [Cu(LH)]2, [Cd(LH)], [Zr(OH)2(OAc)2(LH3)], and [UO2(NO3)(LH2)(MeOH)].

The compounds have been characterized on the basis of elemental analyses, molar conductance, molecular weight, spectral (IR, reflectance, and EPR) studies and magnetic susceptibility measurements.

LH3 behaves as a neutral tridentate ONS donor ligand in [Zr(OH)2(OAc)2(LH3)], monobasic tridentate ONS donor ligand in [UO2(NO3)(LH2)(MeOH)], dibasic tridentate OOS donor ligand in [Cu(LH)]2 and dibasic tetradentate OONO donor ligand in [Mn(LH)(MeOH)2] and [Cd(LH)].

[Cu(LH)]2 is dimer, while all other compounds are monomers in diphenyl.

A square-planar structure for [Cu(LH)]2, a tetrahedral structure for [Cd(LH)], an octahedral structure for [Mn(LH)(MeOH)2], a pentagonal-bipyramidal structure for [Zr(OH)2(OAc)2(LH3)], and an eight-coordinate structure for [UO2(NO3)(LH2)(MeOH)] are proposed.

The ligand (II) and its compounds show antibacterial activities towards E.

coli.

(Gram negative) and S.

aureus (Gram positive).