The Preparation of Matrine Liposome and Its Antiglioma Activity Study

Joint Authors

Han, Shao-Rong
Gong, Hai
Wang, Yan-Ming
Lv, Xiao-Yan
Zhang, Cong
Tong, An-Na
Yuan, Guang-Hui
Zhang, Bao-Yi

Source

Journal of Chemistry

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-07-13

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Chemistry

Abstract EN

The aim of the study was to study the preparation of matrine liposome and its activity for resisting cells, to study the preparation of matrine liposome by orthogonal design, and to observe the inhibiting effect of matrine on glioma through MTT method, Flow Cytometer, and electron microscope.

The results showed that we take the encapsulation efficiency as the index; the optimal preparation of matrine liposome is 100 mg of lecithin, 40 mg of cholesterol, phosphate buffered saline (PBS) with pH value 6.4, and 40 mg of matrine.

The result of MTT testing is shown that the tested group with medium and high dosage (0.75, 1.0, 1.25 mg/L) of matrine has significant inhibiting rate to the growth of BT 325 cells.

The A value in tested group with medium and high dosage is up to 0.19 ± 0.03 .

The methods of Flow Cytometer and electron microscope prove that matrine can inhibit the growth of BT 325 cells.

Matrine is active in inhibiting brain glioma.

American Psychological Association (APA)

Han, Shao-Rong& Gong, Hai& Wang, Yan-Ming& Lv, Xiao-Yan& Zhang, Cong& Tong, An-Na…[et al.]. 2014. The Preparation of Matrine Liposome and Its Antiglioma Activity Study. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1039942

Modern Language Association (MLA)

Han, Shao-Rong…[et al.]. The Preparation of Matrine Liposome and Its Antiglioma Activity Study. Journal of Chemistry No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1039942

American Medical Association (AMA)

Han, Shao-Rong& Gong, Hai& Wang, Yan-Ming& Lv, Xiao-Yan& Zhang, Cong& Tong, An-Na…[et al.]. The Preparation of Matrine Liposome and Its Antiglioma Activity Study. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1039942

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1039942