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The Preparation of Matrine Liposome and Its Antiglioma Activity Study
Joint Authors
Han, Shao-Rong
Gong, Hai
Wang, Yan-Ming
Lv, Xiao-Yan
Zhang, Cong
Tong, An-Na
Yuan, Guang-Hui
Zhang, Bao-Yi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of the study was to study the preparation of matrine liposome and its activity for resisting cells, to study the preparation of matrine liposome by orthogonal design, and to observe the inhibiting effect of matrine on glioma through MTT method, Flow Cytometer, and electron microscope.
The results showed that we take the encapsulation efficiency as the index; the optimal preparation of matrine liposome is 100 mg of lecithin, 40 mg of cholesterol, phosphate buffered saline (PBS) with pH value 6.4, and 40 mg of matrine.
The result of MTT testing is shown that the tested group with medium and high dosage (0.75, 1.0, 1.25 mg/L) of matrine has significant inhibiting rate to the growth of BT 325 cells.
The A value in tested group with medium and high dosage is up to 0.19 ± 0.03 .
The methods of Flow Cytometer and electron microscope prove that matrine can inhibit the growth of BT 325 cells.
Matrine is active in inhibiting brain glioma.
American Psychological Association (APA)
Han, Shao-Rong& Gong, Hai& Wang, Yan-Ming& Lv, Xiao-Yan& Zhang, Cong& Tong, An-Na…[et al.]. 2014. The Preparation of Matrine Liposome and Its Antiglioma Activity Study. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1039942
Modern Language Association (MLA)
Han, Shao-Rong…[et al.]. The Preparation of Matrine Liposome and Its Antiglioma Activity Study. Journal of Chemistry No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1039942
American Medical Association (AMA)
Han, Shao-Rong& Gong, Hai& Wang, Yan-Ming& Lv, Xiao-Yan& Zhang, Cong& Tong, An-Na…[et al.]. The Preparation of Matrine Liposome and Its Antiglioma Activity Study. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1039942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1039942