Age-Related Macular Degeneration: Pathogenesis, Genetic Background, and the Role of Nutritional Supplements
Joint Authors
Moschos, Marilita M.
Nitoda, Eirini
Demopoulos, Constantinos A.
Chatziralli, Irini P.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Age-related macular degeneration (ARMD) is the leading cause of severe vision loss and blindness worldwide, mainly affecting people over 65 years old.
Dry and wet ARDM are the main types of the disease, which seem to have a multifactorial background.
The aim of this review is to summarize the mechanisms of ARMD pathogenesis and exhibit the role of diet and nutritional supplements in the onset and progression of the disease.
Environmental factors, such as smoking, alcohol, and, diet appear to interact with mutations in nuclear and mitochondrial DNA, contributing to the pathogenesis of ARMD.
Inflammatory mediators and oxidative stress, induced by the daily exposure of retina to high pressure of oxygen and light radiation, have been also associated with ARMD lesions.
Other than medical and surgical therapies, nutritional supplements hold a significant role in the prevention and treatment of ARMD, eliminating the progression of macular degeneration.
American Psychological Association (APA)
Moschos, Marilita M.& Nitoda, Eirini& Chatziralli, Irini P.& Demopoulos, Constantinos A.. 2014. Age-Related Macular Degeneration: Pathogenesis, Genetic Background, and the Role of Nutritional Supplements. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1039943
Modern Language Association (MLA)
Moschos, Marilita M.…[et al.]. Age-Related Macular Degeneration: Pathogenesis, Genetic Background, and the Role of Nutritional Supplements. Journal of Chemistry No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1039943
American Medical Association (AMA)
Moschos, Marilita M.& Nitoda, Eirini& Chatziralli, Irini P.& Demopoulos, Constantinos A.. Age-Related Macular Degeneration: Pathogenesis, Genetic Background, and the Role of Nutritional Supplements. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1039943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1039943