Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives
Joint Authors
Sağlık, Begüm Nurpelin
Özkay, Yusuf
Demir Özkay, Ümide
Karaca Gençer, Hülya
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
18 novel dithiocarbamate derivatives were synthesized in order to investigate their inhibitory potency on acetylcholinesterase enzyme and antimicrobial activity.
Structures of the synthesized compounds were elucidated by spectral data and elemental analyses.
The synthesized compounds showed low enzyme inhibitory activity.
However, they displayed good antimicrobial activity profile.
Antibacterial activity of compounds 4a, 4e, and 4p (MIC = 25 μg/mL) was equal to that of chloramphenicol against Klebsiella pneumoniae (ATCC 700603) and Escherichia coli (ATCC 35218).
Most of the compounds exhibited notable antifungal activity against Candida albicans (ATCC 10231), Candida glabrata (ATCC 90030), Candida krusei (ATCC 6258), and Candida parapsilosis (ATCC 7330).
Moreover, compound 4a, which carries piperidin-1-yl substituent and dimethylthiocarbamoyl side chain as variable group, showed twofold better anticandidal effect against all Candida species than reference drug ketoconazole.
American Psychological Association (APA)
Sağlık, Begüm Nurpelin& Özkay, Yusuf& Demir Özkay, Ümide& Karaca Gençer, Hülya. 2014. Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1039972
Modern Language Association (MLA)
Sağlık, Begüm Nurpelin…[et al.]. Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives. Journal of Chemistry No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1039972
American Medical Association (AMA)
Sağlık, Begüm Nurpelin& Özkay, Yusuf& Demir Özkay, Ümide& Karaca Gençer, Hülya. Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1039972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1039972