Fluorine Substituted 1,2,4-Triazinones as Potential Anti-HIV-1 and CDK2 Inhibitors
Joint Authors
Khan, Khalid Ali
Makki, Mohammed Saleh I. T.
Abdel-Rahman, Reda M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Fluorine substituted 1,2,4-triazinones have been synthesized via alkylation, amination, and/or oxidation of 6-(2-amino-5-fluorophenyl)-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one 1 and 4-fluoro-N-(4-fluoro-2-(5-oxo-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)phenyl)benzamide 5 as possible anti-HIV-1 and CDK2 inhibitors.
Alkylation on positions 2 and 4 in 1,2,4-triazinone gave compounds 6–8.
Further modification was performed by selective alkylation and amination on position 3 to form compounds 9–15.
However oxidation of 5 yielded compounds 16–18.
Structures of the target compounds have been established by spectral analysis data.
Five compounds (5, 11, 14, 16, and 17) have shown very good anti-HIV activity in MT-4 cells.
Similarly, five compounds (1, 3, and 14–16) have exhibited very significant CDK2 inhibition activity.
Compounds 14 and 16 were found to have dual anti-HIV and anticancer activities.
American Psychological Association (APA)
Makki, Mohammed Saleh I. T.& Abdel-Rahman, Reda M.& Khan, Khalid Ali. 2014. Fluorine Substituted 1,2,4-Triazinones as Potential Anti-HIV-1 and CDK2 Inhibitors. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1039981
Modern Language Association (MLA)
Makki, Mohammed Saleh I. T.…[et al.]. Fluorine Substituted 1,2,4-Triazinones as Potential Anti-HIV-1 and CDK2 Inhibitors. Journal of Chemistry No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1039981
American Medical Association (AMA)
Makki, Mohammed Saleh I. T.& Abdel-Rahman, Reda M.& Khan, Khalid Ali. Fluorine Substituted 1,2,4-Triazinones as Potential Anti-HIV-1 and CDK2 Inhibitors. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1039981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1039981