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Synthesis and In Vitro and In Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging
Joint Authors
Al-Hokbany, N. S.
Alotaibi, Basim
Bin Amer, Suad
Okarvi, Subhani M.
al-Jammaz, Ibrahim
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In an attempt to develop new tumor imaging radiotracers with favorable biochemical properties, we have synthesized new 68Ga-2-acetylpyridine semicarbazone (68Ga-[APSC]2) as a potential positron emission tomography (PET) tumor imaging agent using a straightforward and a one-step simple reaction.
Radiochemical yield and purity were quantitative without HPLC purification.
Biodistribution studies in nude mice model bearing human MDA-MB-231 cell line xenografts displayed significant tumor uptake of 68Ga-[APSC]2 radiotracer after 2 h postinjection (p.i.).
The initial results demonstrate that 68Ga-[APSC]2 radiotracer may be useful probe for detecting and staging of hypoxic tumor using PET imaging modality.
American Psychological Association (APA)
Al-Hokbany, N. S.& Alotaibi, Basim& Bin Amer, Suad& Okarvi, Subhani M.& al-Jammaz, Ibrahim. 2014. Synthesis and In Vitro and In Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040032
Modern Language Association (MLA)
Al-Hokbany, N. S.…[et al.]. Synthesis and In Vitro and In Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging. Journal of Chemistry No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040032
American Medical Association (AMA)
Al-Hokbany, N. S.& Alotaibi, Basim& Bin Amer, Suad& Okarvi, Subhani M.& al-Jammaz, Ibrahim. Synthesis and In Vitro and In Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040032
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040032