Protective Effects of Elaeagnus angustifolia Leaf Extract against Myocardial IschemiaReperfusion Injury in Isolated Rat Heart
Joint Authors
Zheng, Qiusheng
Wang, Dong
Sun, Xiling
Wang, Binsheng
Qu, Hengyi
Ma, Jun
Xing, Du
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The purpose of this study is to clarify the cardioprotective property of the aqueous extract of Elaeagnus angustifolia L.
leaf (EA) against myocardial ischemia/reperfusion injury in isolated rat heart.
The myocardial ischemia/reperfusion (I/R) injury model of isolated rat heart was set up by the use of improved Langendorff retrograde perfusion technology.
Compared with the ischemia/reperfusion (I/R) group, the aqueous extract of Elaeagnus angustifolia L.
leaf (0.5 mg/mL, 1.0 mg/mL) pretreatment markedly improved the coronary flow (CF) and raised left ventricular developed pressure (LVDP) and maximum rise/down velocity (±dp/dtmax).
The infarct size of the EA-treated hearts was smaller than that of I/R group.
After treatment with EA, the superoxide dismutase (SOD) activity increased; malondialdehyde (MDA) and protein carbonyl content reduced more obviously (P<0.01) than that of I/R injury myocardial tissue.
Conclusion.
Results from the present study showed that the aqueous extract of Elaeagnus angustifolia L.
leaf has obvious protective effects on myocardial I/R injury, which may be related to the improvement of myocardial oxidative stress states.
American Psychological Association (APA)
Wang, Binsheng& Qu, Hengyi& Ma, Jun& Sun, Xiling& Wang, Dong& Zheng, Qiusheng…[et al.]. 2014. Protective Effects of Elaeagnus angustifolia Leaf Extract against Myocardial IschemiaReperfusion Injury in Isolated Rat Heart. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040052
Modern Language Association (MLA)
Wang, Binsheng…[et al.]. Protective Effects of Elaeagnus angustifolia Leaf Extract against Myocardial IschemiaReperfusion Injury in Isolated Rat Heart. Journal of Chemistry No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040052
American Medical Association (AMA)
Wang, Binsheng& Qu, Hengyi& Ma, Jun& Sun, Xiling& Wang, Dong& Zheng, Qiusheng…[et al.]. Protective Effects of Elaeagnus angustifolia Leaf Extract against Myocardial IschemiaReperfusion Injury in Isolated Rat Heart. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040052