The Study of Pyridazine Compounds on Prostanoids: Inhibitors of COX, cAMP Phosphodiesterase, and TXA2 Synthase

Author

Asif, Mohammad

Source

Journal of Chemistry

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-03-13

Country of Publication

Egypt

No. of Pages

16

Main Subjects

Chemistry

Abstract EN

The pyridazine moiety is an important structural feature of various pharmacological active compounds.

Synthetic pyridazine compounds have been reported as effective antiprostaglandins (PGs), 5-lipoxygenase (5-LOX), and antiplatelet agents, that is, inhibitors of prostaglandin or cyclooxygenase (COX-I & COX-II) enzyme, platelet cAMP phosphodiesterase, and thromboxane A2 (TXA2) synthase.

These compounds are selective and nonselective COX inhibitors and showed analgesic, anti-inflammatory, and antipyretic activity.

Pyridazine compounds with antiplatelet agents inhibited TXA2 enzyme.

Pyridazines also exhibited antirheumatoid activity.

These pyridazine compounds hold considerable interest relative to the preparation of organic intermediates and other anticipated biologically active compounds.

American Psychological Association (APA)

Asif, Mohammad. 2014. The Study of Pyridazine Compounds on Prostanoids: Inhibitors of COX, cAMP Phosphodiesterase, and TXA2 Synthase. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1040053

Modern Language Association (MLA)

Asif, Mohammad. The Study of Pyridazine Compounds on Prostanoids: Inhibitors of COX, cAMP Phosphodiesterase, and TXA2 Synthase. Journal of Chemistry No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1040053

American Medical Association (AMA)

Asif, Mohammad. The Study of Pyridazine Compounds on Prostanoids: Inhibitors of COX, cAMP Phosphodiesterase, and TXA2 Synthase. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1040053

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1040053