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The Study of Pyridazine Compounds on Prostanoids: Inhibitors of COX, cAMP Phosphodiesterase, and TXA2 Synthase
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-13
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The pyridazine moiety is an important structural feature of various pharmacological active compounds.
Synthetic pyridazine compounds have been reported as effective antiprostaglandins (PGs), 5-lipoxygenase (5-LOX), and antiplatelet agents, that is, inhibitors of prostaglandin or cyclooxygenase (COX-I & COX-II) enzyme, platelet cAMP phosphodiesterase, and thromboxane A2 (TXA2) synthase.
These compounds are selective and nonselective COX inhibitors and showed analgesic, anti-inflammatory, and antipyretic activity.
Pyridazine compounds with antiplatelet agents inhibited TXA2 enzyme.
Pyridazines also exhibited antirheumatoid activity.
These pyridazine compounds hold considerable interest relative to the preparation of organic intermediates and other anticipated biologically active compounds.
American Psychological Association (APA)
Asif, Mohammad. 2014. The Study of Pyridazine Compounds on Prostanoids: Inhibitors of COX, cAMP Phosphodiesterase, and TXA2 Synthase. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1040053
Modern Language Association (MLA)
Asif, Mohammad. The Study of Pyridazine Compounds on Prostanoids: Inhibitors of COX, cAMP Phosphodiesterase, and TXA2 Synthase. Journal of Chemistry No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1040053
American Medical Association (AMA)
Asif, Mohammad. The Study of Pyridazine Compounds on Prostanoids: Inhibitors of COX, cAMP Phosphodiesterase, and TXA2 Synthase. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1040053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040053