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Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application
Joint Authors
Basri, Mahiran
Da Costa, Stephanie
Shamsudin, Norashikin
Basri, Hamidon
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This paper emphasizes the formation of a positively charged nanoemulsion system for steroid drugs (hydrocortisone).
It is believed that positively charged nanoemulsion provides more effective penetration of the skin.
Therefore in our study we focused on the incorporation of phytosphingosine which serves as a positively charged cosurfactant in the nanoemulsion system.
Negatively charged nanoemulsions were formulated mainly for comparison.
Freshly prepared formulations were formed with particle size less than 300 nm and showed good stability over time.
The oil-in-water nanoemulsion also showed good viscosity, conductivity, and pH values.
From TEM micrograph, particle size showed consistent results with the measurement using photon correlation spectroscopy.
It was concluded that both positively and negatively charged nanoemulsions showed good stability and have great potential in transdermal delivery system.
Though, further investigation of the drug release and drug penetration of both positively and negatively charged nanoemulsions will be studied to further prove the efficacy of nanoemulsion with hydrocortisone as a delivery system for dermal application.
American Psychological Association (APA)
Da Costa, Stephanie& Basri, Mahiran& Shamsudin, Norashikin& Basri, Hamidon. 2014. Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040063
Modern Language Association (MLA)
Da Costa, Stephanie…[et al.]. Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application. Journal of Chemistry No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040063
American Medical Association (AMA)
Da Costa, Stephanie& Basri, Mahiran& Shamsudin, Norashikin& Basri, Hamidon. Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040063