Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular Activities
Joint Authors
Mallikarjunaswamy, C.
Mallesha, Lingappa
Deepu Channe Gowda, Vathsala
Bhadregowda, Doddamedur Giddegowda
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A series of 1-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-3-chloro-4-(2-mercaptoquinolin-3-yl)azetidin-2-one (7a-j) have been synthesized from the condensation of aromatic amines with N-phenylacetamide.
The thione nucleus formed from 2-chloroquionoline-3-carbadehyde using sodium sulphide in dimethyl formamide (DMF) was followed by the reaction with pyrimidine amine to form the Schiff base intermediates.
Attempt has been made to derive final azetidinone analogues from Schiff bases by using chloroacetyl chloride.
The newly synthesized analogues were examined for the antimicrobial activity against some bacterial and fungal strains and in vitro antituberculosis activity against mycobacterium tuberculosis.
These observations provide some predictions to design further antibacterial and antituberculosis active compounds prior to their synthesis according to molecular studies.
American Psychological Association (APA)
Mallikarjunaswamy, C.& Mallesha, Lingappa& Deepu Channe Gowda, Vathsala& Bhadregowda, Doddamedur Giddegowda. 2014. Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular Activities. Journal of Chemistry،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040090
Modern Language Association (MLA)
Mallikarjunaswamy, C.…[et al.]. Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular Activities. Journal of Chemistry No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1040090
American Medical Association (AMA)
Mallikarjunaswamy, C.& Mallesha, Lingappa& Deepu Channe Gowda, Vathsala& Bhadregowda, Doddamedur Giddegowda. Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular Activities. Journal of Chemistry. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040090