Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin
Joint Authors
Khatri, Neeraj
Sagar, Amin
Peddada, Nagesh
Choudhary, Vikas
Chopra, Bhupinder Singh
Garg, Veena
Ashish, Renu
Garg, Renu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The study aims to map plasma gelsolin (pGSN) levels in diabetic humans and mice models of type II diabetes and to evaluate the efficacy of gelsolin therapy in improvement of diabetes in mice.
We report that pGSN values decrease by a factor of 0.45 to 0.5 in the blood of type II diabetic humans and mice models.
Oral glucose tolerance test in mice models showed that subcutaneous administration of recombinant pGSN and its F-actin depolymerizing competent versions brought down blood sugar levels comparable to Sitagliptin, a drug used to manage hyperglycemic condition.
Further, daily dose of pGSN or its truncated versions to diabetic mice for a week kept sugar levels close to normal values.
Also, diabetic mice treated with Sitagliptin for 7 days, showed increase in their pGSN values with the decrease in blood glucose as compared to their levels at the start of treatment.
Gelsolin helped in improving glycemic control in diabetic mice.
We propose that gelsolin level monitoring and replacement of F-actin severing capable gelsolin(s) should be considered in diabetic care.
American Psychological Association (APA)
Khatri, Neeraj& Sagar, Amin& Peddada, Nagesh& Choudhary, Vikas& Chopra, Bhupinder Singh& Garg, Veena…[et al.]. 2014. Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040227
Modern Language Association (MLA)
Khatri, Neeraj…[et al.]. Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin. Journal of Diabetes Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040227
American Medical Association (AMA)
Khatri, Neeraj& Sagar, Amin& Peddada, Nagesh& Choudhary, Vikas& Chopra, Bhupinder Singh& Garg, Veena…[et al.]. Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040227