Small Islets Transplantation Superiority to Large Ones: Implications from Islet Microcirculation and Revascularization
Joint Authors
Li, Wenjuan
Zhao, Ruxing
Liu, Jidong
Tian, Meng
Lu, Yiran
He, Tianyi
Cheng, Meng
Liang, Kai
Li, Xia
Wang, Xiangdong
Sun, Yu
Chen, Li
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Pancreatic islet transplantation is a promising therapy to regain glycemic control in diabetic patients.
The selection of ideal grafts is the basis to guarantee short-term effectivity and longevity of the transplanted islets.
Contradictory to the traditional notion, recent findings implied the superiority of small islets for better transplantation outcomes rather than the large and intact ones.
However, the mechanisms remain to be elucidated.
Recent evidences emphasized the major impact of microcirculation on islet β-cell mass and function.
And potentials in islet graft revascularization are crucial for their survival and preserved function in the recipient.
In this study, we verified the distinct histological phenotype and functionality of small islets versus large ones both in vitro and in vivo.
With efforts to exploring the differences in microcirculation and revascularization of islet grafts, we further evaluated local expressions of angiotensin and vascular endothelial growth factor A (VEGF-A) at different levels.
Our findings reveal that, apart from the higher density of insulin-producing β-cells, small islets express less angiotensin and more angiotrophic VEGF-A.
We therefore hypothesized a logical explanation of the small islet superiority for transplantation outcome from the aspects of facilitated microcirculation and revascularization intrinsically in small islets.
American Psychological Association (APA)
Li, Wenjuan& Zhao, Ruxing& Liu, Jidong& Tian, Meng& Lu, Yiran& He, Tianyi…[et al.]. 2014. Small Islets Transplantation Superiority to Large Ones: Implications from Islet Microcirculation and Revascularization. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040246
Modern Language Association (MLA)
Li, Wenjuan…[et al.]. Small Islets Transplantation Superiority to Large Ones: Implications from Islet Microcirculation and Revascularization. Journal of Diabetes Research No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1040246
American Medical Association (AMA)
Li, Wenjuan& Zhao, Ruxing& Liu, Jidong& Tian, Meng& Lu, Yiran& He, Tianyi…[et al.]. Small Islets Transplantation Superiority to Large Ones: Implications from Islet Microcirculation and Revascularization. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040246