The Class I Histone Deacetylase Inhibitor MS-275 Prevents Pancreatic Beta Cell Death Induced by Palmitate
Joint Authors
Pattou, François
Plaisance, Valérie
Rolland, Laure
Gmyr, Valéry
Annicotte, Jean-Sébastien
Kerr-Conte, Julie
Abderrahmani, Amar
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Elevation of the dietary saturated fatty acid palmitate contributes to the reduction of functional beta cell mass in the pathogenesis of type 2 diabetes.
The diabetogenic effect of palmitate is achieved by increasing beta cell death through induction of the endoplasmic reticulum (ER) stress markers including activating transcription factor 3 (Atf3) and CAAT/enhancer-binding protein homologous protein-10 (Chop).
In this study, we investigated whether treatment of beta cells with the MS-275, a HDAC1 and HDAC3 activity inhibitor which prevents beta cell death elicited by cytokines, is beneficial for combating beta cell dysfunction caused by palmitate.
We show that culture of isolated human islets and MIN6 cells with MS-275 reduced apoptosis evoked by palmitate.
The protective effect of MS-275 was associated with the attenuation of the expression of Atf3 and Chop.
Silencing of HDAC3, but not of HDAC1, mimicked the effects of MS-275 on the expression of the two ER stress markers and apoptosis.
These data point to HDAC3 as a potential drug target for preserving beta cells against lipotoxicity in diabetes.
American Psychological Association (APA)
Plaisance, Valérie& Rolland, Laure& Gmyr, Valéry& Annicotte, Jean-Sébastien& Kerr-Conte, Julie& Pattou, François…[et al.]. 2014. The Class I Histone Deacetylase Inhibitor MS-275 Prevents Pancreatic Beta Cell Death Induced by Palmitate. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040252
Modern Language Association (MLA)
Plaisance, Valérie…[et al.]. The Class I Histone Deacetylase Inhibitor MS-275 Prevents Pancreatic Beta Cell Death Induced by Palmitate. Journal of Diabetes Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040252
American Medical Association (AMA)
Plaisance, Valérie& Rolland, Laure& Gmyr, Valéry& Annicotte, Jean-Sébastien& Kerr-Conte, Julie& Pattou, François…[et al.]. The Class I Histone Deacetylase Inhibitor MS-275 Prevents Pancreatic Beta Cell Death Induced by Palmitate. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040252