Remodeling Intestinal Flora with Sleeve Gastrectomy in Diabetic Rats
Joint Authors
Huang, Xiaofei
Weng, Pan
Zhang, Huixin
Lu, Yingli
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
As a complicated symbiotic system, intestinal flora is reported closely related to the development of type 2 diabetes recently.
Sleeve gastrectomy is one of the approaches of bariatric surgery and could improve blood glucose control in type 2 diabetes patients.
This study was to explore the relationship between remodeled intestinal flora and glucose metabolism in diabetic rats.
Methods.
20 male diabetic rats were operated; 10 of them underwent sleeve gastrectomy, and 10 of them underwent sham operation.
Meanwhile 10 male normal rats underwent sleeve gastrectomy as control.
The animals’ weight and FBG had been measured.
The composition changes of intestinal flora were detected by 16S rDNA sequence analysis.
Results.
In diabetic rats, weight and fasting blood glucose decreased significantly after sleeve gastrectomy.
However, there was no significant change for weight and blood glucose in normal rats after operation.
The intestinal flora of diabetic rats reduced in the proportion of Firmicutes and increased in the proportion of Bacteroidetes after sleeve gastrectomy.
Conclusion.
The change of dominant microorganisms in intestinal flora might play an important role in the glucose metabolism.
American Psychological Association (APA)
Huang, Xiaofei& Weng, Pan& Zhang, Huixin& Lu, Yingli. 2014. Remodeling Intestinal Flora with Sleeve Gastrectomy in Diabetic Rats. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040256
Modern Language Association (MLA)
Huang, Xiaofei…[et al.]. Remodeling Intestinal Flora with Sleeve Gastrectomy in Diabetic Rats. Journal of Diabetes Research No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1040256
American Medical Association (AMA)
Huang, Xiaofei& Weng, Pan& Zhang, Huixin& Lu, Yingli. Remodeling Intestinal Flora with Sleeve Gastrectomy in Diabetic Rats. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040256