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Downregulation of Bcl-2 Expression by miR-34a Mediates Palmitate-Induced Min6 Cells Apoptosis
Joint Authors
Lin, Xiaojie
Guan, Hongyu
Huang, Zhimin
Liu, Juan
Li, Hai
Wei, Guohong
Cao, Xiaopei
Li, Yanbing
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Recent studies have demonstrated that the expression of miR-34a is significantly upregulated and associated with cell apoptosis in pancreatic β-cell treated with palmitate.
Nevertheless, the underlying detailed mechanism is largely unknown.
Here, we showed that miR-34a was significantly induced in Min6 pancreatic β-cell upon palmitate treatment.
Elevated miR-34a promoted Min6 cell apoptosis.
Intriguingly, ectopic expression of miR-34a lowered the expression of Bcl-2, an antiapoptotic protein.
Luciferase reporter assay indicated the direct interaction of miR-34a with the Bcl-2 3′-UTR.
Moreover, downregulated expression of Bcl-2 induced by palmitate could be restored by inhibition of miR-34a.
We conclude that direct suppression of Bcl-2 by miR-34a accounts for palmitate-induced increased apoptosis rate in pancreatic β-cell.
American Psychological Association (APA)
Lin, Xiaojie& Guan, Hongyu& Huang, Zhimin& Liu, Juan& Li, Hai& Wei, Guohong…[et al.]. 2014. Downregulation of Bcl-2 Expression by miR-34a Mediates Palmitate-Induced Min6 Cells Apoptosis. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040278
Modern Language Association (MLA)
Lin, Xiaojie…[et al.]. Downregulation of Bcl-2 Expression by miR-34a Mediates Palmitate-Induced Min6 Cells Apoptosis. Journal of Diabetes Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040278
American Medical Association (AMA)
Lin, Xiaojie& Guan, Hongyu& Huang, Zhimin& Liu, Juan& Li, Hai& Wei, Guohong…[et al.]. Downregulation of Bcl-2 Expression by miR-34a Mediates Palmitate-Induced Min6 Cells Apoptosis. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040278
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040278