The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms
Joint Authors
Jin, Shumei
Zhang, Mixia
Gao, Yan
Zhang, Xuebin
Cui, Guangzhi
Zhang, Yanjun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification.
Therefore, Jing Wan Hong ointment may facilitate the healing of ulcers.
The aim of this study was to evaluate the efficacy and mechanisms of Jing Wan Hong ointment for healing diabetic foot ulceration in Wistar rats induced by streptozotocin and sciatic nerve damage.
The results showed that Jing Wan Hong ointment had a marked effect on foot ulcers in diabetic rats induced by initial nerve injury.
These effects were manifested by reducing the foot ulcer size and Wagner grade after seven days of treatment.
The diabetic rats with foot ulcers were almost healed after 21 days of treatment.
Moreover, the mechanisms of this effect seem to be dependent on increased expression of PDGF mRNA, but there was no influence on the expression of TGF-β, VEGF, and FLT-1 mRNA.
American Psychological Association (APA)
Jin, Shumei& Zhang, Mixia& Gao, Yan& Zhang, Xuebin& Cui, Guangzhi& Zhang, Yanjun. 2014. The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040279
Modern Language Association (MLA)
Jin, Shumei…[et al.]. The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms. Journal of Diabetes Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1040279
American Medical Association (AMA)
Jin, Shumei& Zhang, Mixia& Gao, Yan& Zhang, Xuebin& Cui, Guangzhi& Zhang, Yanjun. The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040279
