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Effect of Metformin Intervention during Pregnancy on the Gestational Diabetes Mellitus in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Joint Authors
Zhuo, Zhihong
Wang, Aiming
Yu, Huimin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Metformin is an effective insulin sensitizer treating type 2 diabetes mellitus.
However, the functional consequences of metformin administration throughout pregnancy on gestational diabetes mellitus (GDM) with polycystic ovary syndrome (PCOS) have not been assessed.
We therefore performed a meta-analysis and system review to determine the effect of metformin on GDM in PCOS.
A meta-analysis was performed on the published studies before December, 2013.
Meta-analysis examined whether metformin could reduce GDM occurrence in PCOS with a fixed effect model.
The odds ratio (OR) with 95% confidence interval (95% CI) was calculated to estimate the strength of association.
A total of 13 studies including 5 RCTs and 8 non-RCTs were enrolled.
Ultimately, effectiveness analysis demonstrated that, in total, there was no significant availability of metformin on GDM in PCOS in contrast to placebo (OR = 1.07, 95% CI 0.60–1.92) in RCTs and significant availability of metformin on GDM (OR = 0.19, 95% CI 0.13–0.27) was indicated in non-RCTs.
In summary, according to the results of our meta-analysis, strictly, metformin did not significantly effect on GDM with PCOS, though more multicenters RCTs still need to be investigated.
American Psychological Association (APA)
Zhuo, Zhihong& Wang, Aiming& Yu, Huimin. 2014. Effect of Metformin Intervention during Pregnancy on the Gestational Diabetes Mellitus in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040292
Modern Language Association (MLA)
Zhuo, Zhihong…[et al.]. Effect of Metformin Intervention during Pregnancy on the Gestational Diabetes Mellitus in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Journal of Diabetes Research No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1040292
American Medical Association (AMA)
Zhuo, Zhihong& Wang, Aiming& Yu, Huimin. Effect of Metformin Intervention during Pregnancy on the Gestational Diabetes Mellitus in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040292