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Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets
Joint Authors
Tebourbi, Olfa
Missaoui, Samira
Ben Rhouma, Khémais
Yacoubi, Mohamed-Tahar
Sakly, Mohsen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We examined the effects of vanadium sulfate (VOSO4) treatment at 5 and 10 mg/kg for 30 days on endocrine pancreas activity and histology in nondiabetic and STZ-induced diabetic rats.
In diabetic group, blood glucose levels significantly increased while insulinemia level markedly decreased.
At the end of treatment, VOSO4 at a dose of 10 mg/Kg normalized blood glucose level in diabetic group, restored insulinemia, and significantly improved insulin sensitivity.
VOSO4 also increased in a dose-dependent manner the number of insulin immunopositive beta cells in pancreatic islets of nondiabetic rats.
Furthermore, in the STZ-diabetic group, the decrease in the number of insulin immunopositive beta cells was corrected to reach the control level mainly with the higher dose of vanadium.
Therefore, VOSO4 treatment normalized plasma glucose and insulin levels and improved insulin sensitivity in STZ-experimental diabetes and induced beta cells proliferation and/or regeneration in normal or diabetic rats.
American Psychological Association (APA)
Missaoui, Samira& Ben Rhouma, Khémais& Yacoubi, Mohamed-Tahar& Sakly, Mohsen& Tebourbi, Olfa. 2014. Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040308
Modern Language Association (MLA)
Missaoui, Samira…[et al.]. Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets. Journal of Diabetes Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040308
American Medical Association (AMA)
Missaoui, Samira& Ben Rhouma, Khémais& Yacoubi, Mohamed-Tahar& Sakly, Mohsen& Tebourbi, Olfa. Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040308