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Impact of Bariatric Surgery on Ghrelin and Obestatin Levels in Obesity or Type 2 Diabetes Mellitus Rat Model
Joint Authors
Zhou, Donglei
Jiang, Xun
Ding, Weixing
Zhang, Dingyu
Yang, Lei
Zhen, Chengzhu
Lu, Liesheng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We aimed to evaluate the therapeutic efficacy on weight control by different bariatric surgeries and investigate the ghrelin and obestatin changes after these surgeries in obesity and nonobese type 2 diabetes mellitus (T2DM) rats.
Obese rats were randomly assigned to receive sleeve gastrectomy (SG, n = 8 ), minigastric bypass (MGBP, n = 8 ), roux-en-Y gastric bypass (RYGBP, n = 8 ), and sham operation (SO, n = 4 ).
Another 4 rats served as control.
Besides, Goto-Kakisaki (GK) rats were also randomly divided into similar groups except for total gastrectomy (TG, n = 8 ) group.
The results showed that in obese rats, weigh loss in RYGBP group was similar to that in MGBP group but larger than that in SG group.
Ghrelin significantly increased in RYGB group, but obestatin increased in MGBP group.
Ghrelin/obestatin ratio significantly decreased in SG group.
In GK rats, weight loss was most obvious in TG group.
Postoperatively, ghrelin was significantly increased in MGBP and RYGB groups but decreased in TG group.
Obestatin also showed an increase in MGBP and RYGB groups.
Ghrelin/obestatin in TG group decreased significantly.
In conclusion, RYGB and MGBP may be more suitable for obese rats, but TG may be the best strategy for T2DM rats to control weight with different mechanisms.
American Psychological Association (APA)
Zhou, Donglei& Jiang, Xun& Ding, Weixing& Zhang, Dingyu& Yang, Lei& Zhen, Chengzhu…[et al.]. 2014. Impact of Bariatric Surgery on Ghrelin and Obestatin Levels in Obesity or Type 2 Diabetes Mellitus Rat Model. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040312
Modern Language Association (MLA)
Zhou, Donglei…[et al.]. Impact of Bariatric Surgery on Ghrelin and Obestatin Levels in Obesity or Type 2 Diabetes Mellitus Rat Model. Journal of Diabetes Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040312
American Medical Association (AMA)
Zhou, Donglei& Jiang, Xun& Ding, Weixing& Zhang, Dingyu& Yang, Lei& Zhen, Chengzhu…[et al.]. Impact of Bariatric Surgery on Ghrelin and Obestatin Levels in Obesity or Type 2 Diabetes Mellitus Rat Model. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040312