Role of MicroRNAs in Islet Beta-Cell Compensation and Failure during Diabetes
Joint Authors
Plaisance, Valérie
Abderrahmani, Amar
Waeber, Gérard
Regazzi, Romano
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Pancreatic beta-cell function and mass are markedly adaptive to compensate for the changes in insulin requirement observed during several situations such as pregnancy, obesity, glucocorticoids excess, or administration.
This requires a beta-cell compensation which is achieved through a gain of beta-cell mass and function.
Elucidating the physiological mechanisms that promote functional beta-cell mass expansion and that protect cells against death, is a key therapeutic target for diabetes.
In this respect, several recent studies have emphasized the instrumental role of microRNAs in the control of beta-cell function.
MicroRNAs are negative regulators of gene expression, and are pivotal for the control of beta-cell proliferation, function, and survival.
On the one hand, changes in specific microRNA levels have been associated with beta-cell compensation and are triggered by hormones or bioactive peptides that promote beta-cell survival and function.
Conversely, modifications in the expression of other specific microRNAs contribute to beta-cell dysfunction and death elicited by diabetogenic factors including, cytokines, chronic hyperlipidemia, hyperglycemia, and oxidized LDL.
This review underlines the importance of targeting the microRNA network for future innovative therapies aiming at preventing the beta-cell decline in diabetes.
American Psychological Association (APA)
Plaisance, Valérie& Waeber, Gérard& Regazzi, Romano& Abderrahmani, Amar. 2014. Role of MicroRNAs in Islet Beta-Cell Compensation and Failure during Diabetes. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040316
Modern Language Association (MLA)
Plaisance, Valérie…[et al.]. Role of MicroRNAs in Islet Beta-Cell Compensation and Failure during Diabetes. Journal of Diabetes Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1040316
American Medical Association (AMA)
Plaisance, Valérie& Waeber, Gérard& Regazzi, Romano& Abderrahmani, Amar. Role of MicroRNAs in Islet Beta-Cell Compensation and Failure during Diabetes. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040316