Proinflammatory and Prothrombotic State in Subjects with Different Glucose Tolerance Status before Cardiovascular Disease
Joint Authors
Isordia-Salas, Irma
Santiago-Germán, David
Galván-Plata, María Eugenia
Leaños-Miranda, Alfredo
Aguilar-Sosa, Eberth
Majluf-Cruz, Abraham
Anaya-Gómez, Francisco
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Inflammation has been associated with insulin resistance, type 2 diabetes mellitus (T2DM), and atherothrombosis.
Aim.
To determine differences in levels of proinflammatory and prothrombotic markers such as high sensitivity C-reactive protein (hs-CRP) and fibrinogen in subjects with normal glucose tolerance (NGT), prediabetes, and T2DM and to establish their relationship with other cardiovascular risk factors before clinical manifestations of cardiovascular disease.
Methods.
We conducted a nonrandomized, cross-sectional assay in a hospital at México City.
The levels of hs-CRP and fibrinogen were measured and compared according to glucose tolerance status.
Results.
We enrolled 1047 individuals and they were distributed into NGT n=473, pre-DM n=250, and T2DM n=216.
There was a statistical difference between NGT and T2DM groups for fibrinogen (P=0.01) and hs-CRP (P=0.05).
Fibrinogen and hs-CRP showed a significant positive correlation coefficient (r=0.53, P<0.0001).
In a multiple stepwise regression analysis, the variability in fibrinogen levels was explained by age, HbA1c, and hs-CRP (adjusted R2=0.31, P<0.0001), and for hs-CRP it was explained by BMI and fibrinogen (adjusted R2=0.33, P<0.0001).
Conclusion.
Inflammation and prothrombotic state are present in people with T2DM lacking cardiovascular disease.
Fibrinogen and Hs-CRP are positively correlated.
Fibrinogen and hs-CRP concentrations are predominantly determined by BMI rather than glucose levels.
American Psychological Association (APA)
Isordia-Salas, Irma& Galván-Plata, María Eugenia& Leaños-Miranda, Alfredo& Aguilar-Sosa, Eberth& Anaya-Gómez, Francisco& Majluf-Cruz, Abraham…[et al.]. 2014. Proinflammatory and Prothrombotic State in Subjects with Different Glucose Tolerance Status before Cardiovascular Disease. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040321
Modern Language Association (MLA)
Isordia-Salas, Irma…[et al.]. Proinflammatory and Prothrombotic State in Subjects with Different Glucose Tolerance Status before Cardiovascular Disease. Journal of Diabetes Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1040321
American Medical Association (AMA)
Isordia-Salas, Irma& Galván-Plata, María Eugenia& Leaños-Miranda, Alfredo& Aguilar-Sosa, Eberth& Anaya-Gómez, Francisco& Majluf-Cruz, Abraham…[et al.]. Proinflammatory and Prothrombotic State in Subjects with Different Glucose Tolerance Status before Cardiovascular Disease. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040321