Glyoxylate, a New Marker Metabolite of Type 2 Diabetes
Joint Authors
Looser, R.
Nikiforova, Victoria J.
Giesbertz, Pieter
Wiemer, Jan
Bethan, Bianca
Liebenberg, Volker
Ruiz Noppinger, Patricia
Daniel, Hannelore
Rein, Dietrich
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Type 2 diabetes (T2D) is characterized by a variety of metabolic impairments that are closely linked to nonenzymatic glycation reactions of proteins and peptides resulting in advanced glycation end-products (AGEs).
Reactive aldehydes derived from sugars play an important role in the generation of AGEs.
Using metabolite profiling to characterize human plasma from diabetic versus nondiabetic subjects we observed in a recent study that the reactive aldehyde glyoxylate was increased before high levels of plasma glucose, typical for a diabetic condition, could be measured.
Following this observation, we explored the relevance of increased glyoxylate in diabetic subjects and in diabetic C57BLKS/J-Leprdb/db-/- mice in the pathophysiology of diabetes.
A retrospective study using samples of long-term blood donors revealed that glyoxylate levels unlike glucose levels became significantly elevated up to 3 years prior to diabetes diagnosis (difference to control P=0.034).
Elevated glyoxylate levels impact on newly identified mechanisms linking hyperglycemia and AGE production with diabetes-associated complications such as diabetic nephropathy.
Glyoxylate in its metabolic network may serve as an early marker in diabetes diagnosis with predictive qualities for associated complications and as potential to guide the development of new antidiabetic therapies.
American Psychological Association (APA)
Nikiforova, Victoria J.& Giesbertz, Pieter& Wiemer, Jan& Bethan, Bianca& Looser, R.& Liebenberg, Volker…[et al.]. 2014. Glyoxylate, a New Marker Metabolite of Type 2 Diabetes. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040326
Modern Language Association (MLA)
Nikiforova, Victoria J.…[et al.]. Glyoxylate, a New Marker Metabolite of Type 2 Diabetes. Journal of Diabetes Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1040326
American Medical Association (AMA)
Nikiforova, Victoria J.& Giesbertz, Pieter& Wiemer, Jan& Bethan, Bianca& Looser, R.& Liebenberg, Volker…[et al.]. Glyoxylate, a New Marker Metabolite of Type 2 Diabetes. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040326
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040326