Subjects with Impaired Fasting Glucose: Evolution in a Period of 6 Years

Abstract EN

Aim.

To study the evolution of impaired fasting glucose (IFG), considering glucose and HbA1c levels and risk factors associated, in a period of 6 years.

Methods.

We studied 94 subjects with impaired fasting glucose (IFG) that were diagnosed in 2005 and followed up to 2012.

Glucose and HbA1c levels were determined.

A descriptive analysis of contingence charts was performed in order to study the evolution in the development of type-2 diabetes mellitus (T2DM).

Results.

Twenty-eight of ninety-four subjects became T2DM; 51/94 remained with IFG; and 20/94 presented normal fasting glucose.

From the 28 diabetic subjects, 9 had already developed diabetes and were under treatment with oral hypoglycemic agents; 5 were diagnosed with plasma glucose < 126 mg/dL, but with HbA1c over 6.5%.

In those who developed diabetes, 15/28 had a family history of T2DM in first relative degree.

Also, diabetic subjects had a BMI significantly higher than nodiabetics (t test: P < 0.01).

The individuals that in 2005 had the highest BMI are those who currently have diabetes.

Conclusion.

The IFG constitutes a condition of high risk of developing T2DM in a few years, especially over 110 mg/dL and in obesity patients.