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Vitamin Status as a Determinant of Serum Homocysteine Concentration in Type 2 Diabetic Retinopathy
Joint Authors
Raptis, A. E.
Fotiou, Pandelis
Apergis, George
Vergados, Ioannis
Theodossiadis, Panagiotis
Dimitriadis, George
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy.
This study included 65 patients with and 75 patients without diabetic retinopathy.
Patients with diabetic retinopathy had significantly higher serum homocysteine levels P < 0.001 , higher prevalence of hyperhomocysteinemia P < 0.001 , lower serum folic acid P < 0.001 , and vitamin B12 ( P = 0.014 ) levels than those without diabetic retinopathy.
Regression analysis revealed that homocysteine was an independent risk factor for diabetic retinopathy and there was a threshold in its serum level (13.7 μmol/L), above which the risk of diabetic retinopathy greatly increases ( O R = 1.66 , P = 0.001 ).
Folic acid was associated with decreased odds for diabetic retinopathy ( O R = 0.73 , P < 0.001 ).
There was a threshold in serum vitamin B12 level (248.4 pg/mL), below which serum homocysteine concentration significantly increases with decreasing serum vitamin B12 ( P = 0.003 ).
Our findings suggest that hyperhomocysteinemia is an independent risk factor for the development and progression of diabetic retinopathy.
Decreased serum levels of folic acid and vitamin B12, through raising serum homocysteine concentrations, may also affect the diabetic retinopathy risk.
American Psychological Association (APA)
Fotiou, Pandelis& Raptis, A. E.& Apergis, George& Dimitriadis, George& Vergados, Ioannis& Theodossiadis, Panagiotis. 2014. Vitamin Status as a Determinant of Serum Homocysteine Concentration in Type 2 Diabetic Retinopathy. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040378
Modern Language Association (MLA)
Fotiou, Pandelis…[et al.]. Vitamin Status as a Determinant of Serum Homocysteine Concentration in Type 2 Diabetic Retinopathy. Journal of Diabetes Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040378
American Medical Association (AMA)
Fotiou, Pandelis& Raptis, A. E.& Apergis, George& Dimitriadis, George& Vergados, Ioannis& Theodossiadis, Panagiotis. Vitamin Status as a Determinant of Serum Homocysteine Concentration in Type 2 Diabetic Retinopathy. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040378