JNK3 Is Required for the Cytoprotective Effect of Exendin 4
Joint Authors
Pattou, François
Gmyr, Valéry
Kerr-Conte, Julie
Abderrahmani, Amar
Ezanno, Hélène
Pawlowski, Valérie
Abdelli, Saida
Boutry, Raphael
Bonny, Christophe
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Preservation of beta cell against apoptosis is one of the therapeutic benefits of the glucagon-like peptide-1 (GLP1) antidiabetic mimetics for preserving the functional beta cell mass exposed to diabetogenic condition including proinflammatory cytokines.
The mitogen activated protein kinase 10 also called c-jun amino-terminal kinase 3 (JNK3) plays a protective role in insulin-secreting cells against death caused by cytokines.
In this study, we investigated whether the JNK3 expression is associated with the protective effect elicited by the GLP1 mimetic exendin 4.
We found an increase in the abundance of JNK3 in isolated human islets and INS-1E cells cultured with exendin 4.
Induction of JNK3 by exendin 4 was associated with an increased survival of INS-1E cells.
Silencing of JNK3 prevented the cytoprotective effect of exendin 4 against apoptosis elicited by culture condition and cytokines.
These results emphasize the requirement of JNK3 in the antiapoptotic effects of exendin 4.
American Psychological Association (APA)
Ezanno, Hélène& Pawlowski, Valérie& Abdelli, Saida& Boutry, Raphael& Gmyr, Valéry& Kerr-Conte, Julie…[et al.]. 2014. JNK3 Is Required for the Cytoprotective Effect of Exendin 4. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040380
Modern Language Association (MLA)
Ezanno, Hélène…[et al.]. JNK3 Is Required for the Cytoprotective Effect of Exendin 4. Journal of Diabetes Research No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1040380
American Medical Association (AMA)
Ezanno, Hélène& Pawlowski, Valérie& Abdelli, Saida& Boutry, Raphael& Gmyr, Valéry& Kerr-Conte, Julie…[et al.]. JNK3 Is Required for the Cytoprotective Effect of Exendin 4. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040380