Renal Protective Effect of Sirtuin 1
Joint Authors
Dong, Yi-jun
Liu, Nian
Xiao, Zhi
Sun, Tao
Wu, Shu-hui
Sun, Wei-xia
Xu, Zhong-gao
Yuan, Hang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Silent information regulator 2 (Sir2) is a nicotinamide adenine dinucleotide- (NAD+-) dependent deacetylase.
The homology of SIRT1 and Sir2 has been extensively studied.
SIRT1 deacetylates target proteins using the coenzyme NAD+ and is therefore linked to cellular energy metabolism and the redox state through multiple signalling and survival pathways.
During the past decade, investigators have reported that SIRT1 activity is essential in cancer, neurodegenerative diseases, diabetes, cardiovascular disease, and other age-related diseases.
In the kidneys, SIRT1 may inhibit renal cell apoptosis, inflammation, and fibrosis.
Therefore its activation may also become a new therapeutic target in the patients with chronic kidney disease including diabetic nephropathy.
In this paper, we would like to review the protective functions of sirtuins and the role of SIRT1 in the onset of kidney disease based on previous studies, including diabetic nephropathy, acute renal injury, chronic kidney disease as well as lupus nephritis.
American Psychological Association (APA)
Dong, Yi-jun& Liu, Nian& Xiao, Zhi& Sun, Tao& Wu, Shu-hui& Sun, Wei-xia…[et al.]. 2014. Renal Protective Effect of Sirtuin 1. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040385
Modern Language Association (MLA)
Dong, Yi-jun…[et al.]. Renal Protective Effect of Sirtuin 1. Journal of Diabetes Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040385
American Medical Association (AMA)
Dong, Yi-jun& Liu, Nian& Xiao, Zhi& Sun, Tao& Wu, Shu-hui& Sun, Wei-xia…[et al.]. Renal Protective Effect of Sirtuin 1. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040385