miR-375 and miR-30d in the Effect of Chromium-Containing Chinese Medicine Moderating Glucose Metabolism
Joint Authors
Zhang, Qian
Li, Wenhui
Zheng, Jia
Xiao, Xinhua
Li, Ming
Yu, Miao
Zhang, Huabing
Ping, Fan
Wang, Zhixin
Xiang, Hongding
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In China, TianMai Xiaoke tablet (TM) is used to treat type 2 diabetes.
However, the exact mechanism of TM is not clear.
This study is to investigate the effect of TM on glucose metabolism in diabetic rats and to identify whether TM takes a direct action through microRNAs on islet.
Rats were divided into control group, diabetic group, low dose of TM group (TML), and high dose of TM group (TMH).
Pancreas samples were analyzed using microRNA array and Q-PCR.
Eight-week treatment with TM significantly decreased fasting blood glucose.
The blood glucose was significantly reduced in TM-treated groups before and after oral glucose administration.
Fasting insulin and HOMA-IR were suppressed in TM-treated groups.
miR-448, let-7b, miR-540, miR-296, miR-880, miR-200a, miR-500, miR-10b, miR-336, miR-30d, miR-208, let-7e, miR-142-5p, miR-874, miR-375, miR-879, miR-501, and miR-188 were upregulated, while miR-301b, miR-134, and miR-652 were downregulated in TMH group.
Through target gene analysis and real-time PCR verification, we found that these miRNAs, especially miR-375 and miR-30d, can stimulate insulin secretion in islet.
Our data suggest that TM can improve blood glucose in diabetic rats which involved increasing the expression of miR-375 and miR-30d to activate insulin synthesis in islet.
American Psychological Association (APA)
Zhang, Qian& Xiao, Xinhua& Li, Ming& Li, Wenhui& Yu, Miao& Zhang, Huabing…[et al.]. 2014. miR-375 and miR-30d in the Effect of Chromium-Containing Chinese Medicine Moderating Glucose Metabolism. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040389
Modern Language Association (MLA)
Zhang, Qian…[et al.]. miR-375 and miR-30d in the Effect of Chromium-Containing Chinese Medicine Moderating Glucose Metabolism. Journal of Diabetes Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040389
American Medical Association (AMA)
Zhang, Qian& Xiao, Xinhua& Li, Ming& Li, Wenhui& Yu, Miao& Zhang, Huabing…[et al.]. miR-375 and miR-30d in the Effect of Chromium-Containing Chinese Medicine Moderating Glucose Metabolism. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040389