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Role of Ink4aArf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions
Joint Authors
Annicotte, Jean-Sébastien
Rabhi, Nabil
Salas, Elisabet
Froguel, Philippe
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The ARF/INK4A (Cdkn2a) locus includes the linked tumour suppressor genes p16INK4a and p14ARF (p19ARF in mice) that trigger the antiproliferative activities of both RB and p53.
With beta cell self-replication being the primary source for new beta cell generation in adult animals, the network by which beta cell replication could be increased to enhance beta cell mass and function is one of the approaches in diabetes research.
In this review, we show a general view of the regulation points at transcriptional and posttranslational levels of Cdkn2a locus.
We describe the molecular pathways and functions of Cdkn2a in beta cell cycle regulation.
Given that aging reveals increased p16Ink4a levels in the pancreas that inhibit the proliferation of beta cells and decrease their ability to respond to injury, we show the state of the art about the role of this locus in beta cell senescence and diabetes development.
Additionally, we focus on two approaches in beta cell regeneration strategies that rely on Cdkn2a locus negative regulation: long noncoding RNAs and betatrophin.
American Psychological Association (APA)
Salas, Elisabet& Rabhi, Nabil& Froguel, Philippe& Annicotte, Jean-Sébastien. 2014. Role of Ink4aArf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040393
Modern Language Association (MLA)
Salas, Elisabet…[et al.]. Role of Ink4aArf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions. Journal of Diabetes Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040393
American Medical Association (AMA)
Salas, Elisabet& Rabhi, Nabil& Froguel, Philippe& Annicotte, Jean-Sébastien. Role of Ink4aArf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040393