Urinary Methylmalonic Acid as an Indicator of Early Vitamin B12 Deficiency and Its Role in Polyneuropathy in Type 2 Diabetes
Joint Authors
Sun, Ai-li
Ni, Yi-hong
Li, Xiao-bo
Zhuang, Xiang-hua
Liu, Yuan-tao
Liu, Xin-hua
Chen, Shi-hong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The rising incidence of diabetes and its negative impact on quality of life highlights the urgent need to develop biomarkers of early nerve damage.
Measurement of total vitamin B12 has some limitations.
We want to determine the levels of urinary methylmalonic acid and its relationships with serum vitamin B12 and polyneuropathy.
The 176 Chinese patients with Type 2 diabetes mellitus were divided into 3 groups according to the levels of vitamin B12.
A gas chromatography mass spectrometric technique was used to determine blood methylmalonic acid and urinary methylmalonic acid.
The diagnosis of distal diabetic polyneuropathy was based on the determination of bilateral limb sensory and motor nerve conduction velocity and amplitude with electromyogram.
Multiple regression analysis revealed that urinary methylmalonic acid/creatinine, blood methylmalonic acid, and so forth were variables that influenced diabetic polyneuropathy significantly.
Nerve sensory conduction velocity and nerve amplitude in the group of urinary methylmalonic acid/creatinine >3.5 mmol/mol decreased significantly.
Superficial peroneal nerve sensory and motor conduction velocity and ulnar nerve compound motor active potential amplitude were inversely correlated with urinary methylmalonic acid/creatinine.
Urinary methylmalonic acid correlates with serum vitamin B12 levels in person with diabetes and is a sensitive marker of early polyneuropathy.
American Psychological Association (APA)
Sun, Ai-li& Ni, Yi-hong& Li, Xiao-bo& Zhuang, Xiang-hua& Liu, Yuan-tao& Liu, Xin-hua…[et al.]. 2014. Urinary Methylmalonic Acid as an Indicator of Early Vitamin B12 Deficiency and Its Role in Polyneuropathy in Type 2 Diabetes. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040397
Modern Language Association (MLA)
Sun, Ai-li…[et al.]. Urinary Methylmalonic Acid as an Indicator of Early Vitamin B12 Deficiency and Its Role in Polyneuropathy in Type 2 Diabetes. Journal of Diabetes Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040397
American Medical Association (AMA)
Sun, Ai-li& Ni, Yi-hong& Li, Xiao-bo& Zhuang, Xiang-hua& Liu, Yuan-tao& Liu, Xin-hua…[et al.]. Urinary Methylmalonic Acid as an Indicator of Early Vitamin B12 Deficiency and Its Role in Polyneuropathy in Type 2 Diabetes. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040397