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Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy
Joint Authors
Xu, Qing-yan
Qi, Lei
Wang, Yu-bin
Li, Xiu-juan
Zheng, Ma-li
Zhong, Rui-sheng
Zhang, Yi
Xu, Xiang-dong
Wu, Bo-le
Zhu, Hong
Xu, Zhu-mei
Lu, Xiang-hong
Lin, Yuan
Xiao, Ye-cheng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of the study was to assess serum fibroblast growth factor 21 (FGF21) concentrations in Chinese type 2 diabetic patients with and without retinopathy and to assess the association between FGF21 and the severity of retinopathy.
117 diabetic patients were compared with 68 healthy controls.
Fasting blood glucose, serum total cholesterol, serum triglycerides, serum insulin, and serum FGF21 levels were estimated.
FGF21 concentrations in the patients were significantly higher than those in control.
In the patient group there was a significant positive correlation between FGF21, insulin level, and homeostasis model assessment index.
Serum FGF21 concentrations in patients with proliferative diabetic retinopathy or nonproliferative diabetic retinopathy were significantly higher than those in patients without diabetic retinopathy.
When the presence of diabetes was defined as the final variable in the conditional logistic regression model with the FGF21 concentration as the continuous variable, FGF21 was significantly involved in the model.
This study shows that the increase in serum concentration of FGF21 was associated with the severity of diabetic retinopathy and suggests that FGF21 may play a role in the pathogenesis of diabetic retinopathy and its degree.
American Psychological Association (APA)
Lin, Yuan& Xiao, Ye-cheng& Zhu, Hong& Xu, Qing-yan& Qi, Lei& Wang, Yu-bin…[et al.]. 2014. Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040399
Modern Language Association (MLA)
Lin, Yuan…[et al.]. Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy. Journal of Diabetes Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040399
American Medical Association (AMA)
Lin, Yuan& Xiao, Ye-cheng& Zhu, Hong& Xu, Qing-yan& Qi, Lei& Wang, Yu-bin…[et al.]. Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040399