Injury to the Endothelial Surface Layer Induces Glomerular Hyperfiltration Rats with Early-Stage Diabetes
Joint Authors
Zhang, Chunyang
Meng, Yao
Liu, Qi
Xuan, Miao
Zhang, Lanyu
Deng, Bo
Zhang, Keqin
Liu, Zhimin
Lei, Tao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Glomerular endothelial surface layer (ESL) may play a role in the mechanisms of albuminuria in diabetic nephropathy, which lack evidence in vivo.
The effects of high glucose on the passage of albumin across the glomerular ESL were analysed in streptozotocin-induced diabetic Sprague-Dawley rats for 4 weeks.
Albuminuria and glomerular mesangial matrix were significantly increased in diabetic rats.
The passage of albumin across the ESL, as measured by albumin-colloid gold particle density in the glomerular basement membrane (GBM), was increased significantly in diabetic rats.
The thickness of the glomerular ESL, examined indirectly by infusing Intralipid into vessels using an electron microscope, was significantly decreased and the GBM exhibited little change in diabetic rats.
In summary, the glomerular ESL may play a role in the pathogenesis of albuminuria in rats with early-stage diabetes.
American Psychological Association (APA)
Zhang, Chunyang& Meng, Yao& Liu, Qi& Xuan, Miao& Zhang, Lanyu& Deng, Bo…[et al.]. 2014. Injury to the Endothelial Surface Layer Induces Glomerular Hyperfiltration Rats with Early-Stage Diabetes. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040402
Modern Language Association (MLA)
Zhang, Chunyang…[et al.]. Injury to the Endothelial Surface Layer Induces Glomerular Hyperfiltration Rats with Early-Stage Diabetes. Journal of Diabetes Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040402
American Medical Association (AMA)
Zhang, Chunyang& Meng, Yao& Liu, Qi& Xuan, Miao& Zhang, Lanyu& Deng, Bo…[et al.]. Injury to the Endothelial Surface Layer Induces Glomerular Hyperfiltration Rats with Early-Stage Diabetes. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040402