Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus
Joint Authors
Boyuk, Banu
Degirmencioglu, Serife
Atalay, Hande
Guzel, Savas
Acar, Ayse
Celebi, Aslan
Ekizoglu, Ismail
Simsek, Caglar
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Aim.
Studies have suggested that brain-derived neurotrophic factor (BDNF) plays a role in glucose and lipid metabolism and inflammation.
The aim of this study was to evaluate the relationship between serum BDNF levels and various metabolic parameters and inflammatory markers in patients with type 2 diabetes mellitus (T2DM).
Materials and Methods.
The study included 88 T2DM patients and 33 healthy controls.
Fasting blood samples were obtained from the patients and the control group.
The serum levels of BDNF were measured with an ELISA kit.
The current paper introduces a receiver-operating characteristic (ROC) generalization curve to identify cut-off for the BDNF values in type 2 diabetes patients.
Results.
The serum levels of BDNF were significantly higher in T2DM patients than in the healthy controls (206.81 ± 107.32 pg/mL versus 130.84 ± 59.81 pg/mL; P<0.001).
They showed a positive correlation with the homeostasis model assessment of insulin resistance (HOMA-IR) (r=0.28; P<0.05), the triglyceride level (r=0.265; P<0.05), and white blood cell (WBC) count (r=0.35; P<0.001).
In logistic regression analysis, age (P<0.05), body mass index (BMI) (P<0.05), C-reactive protein (CRP) (P<0.05), and BDNF (P<0.01) were independently associated with T2DM.
In ROC curve analysis, BDNF cut-off was 137.
Conclusion.
The serum BDNF level was higher in patients with T2DM.
The BDNF had a cut-off value of 137.
The findings suggest that BDNF may contribute to glucose and lipid metabolism and inflammation.
American Psychological Association (APA)
Boyuk, Banu& Degirmencioglu, Serife& Atalay, Hande& Guzel, Savas& Acar, Ayse& Celebi, Aslan…[et al.]. 2014. Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040405
Modern Language Association (MLA)
Boyuk, Banu…[et al.]. Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040405
American Medical Association (AMA)
Boyuk, Banu& Degirmencioglu, Serife& Atalay, Hande& Guzel, Savas& Acar, Ayse& Celebi, Aslan…[et al.]. Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040405