Predicting Alloreactivity in Transplantation
Joint Authors
Geneugelijk, Kirsten
Thus, Kirsten Anne
Spierings, Eric
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Human leukocyte Antigen (HLA) mismatching leads to severe complications after solid-organ transplantation and hematopoietic stem-cell transplantation.
The alloreactive responses underlying the posttransplantation complications include both direct recognition of allogeneic HLA by HLA-specific alloantibodies and T cells and indirect T-cell recognition.
However, the immunogenicity of HLA mismatches is highly variable; some HLA mismatches lead to severe clinical B-cell- and T-cell-mediated alloreactivity, whereas others are well tolerated.
Definition of the permissibility of HLA mismatches prior to transplantation allows selection of donor-recipient combinations that will have a reduced chance to develop deleterious host-versus-graft responses after solid-organ transplantation and graft-versus-host responses after hematopoietic stem-cell transplantation.
Therefore, several methods have been developed to predict permissible HLA-mismatch combinations.
In this review we aim to give a comprehensive overview about the current knowledge regarding HLA-directed alloreactivity and several developed in vitro and in silico tools that aim to predict direct and indirect alloreactivity.
American Psychological Association (APA)
Geneugelijk, Kirsten& Thus, Kirsten Anne& Spierings, Eric. 2014. Predicting Alloreactivity in Transplantation. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040778
Modern Language Association (MLA)
Geneugelijk, Kirsten…[et al.]. Predicting Alloreactivity in Transplantation. Journal of Immunology Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1040778
American Medical Association (AMA)
Geneugelijk, Kirsten& Thus, Kirsten Anne& Spierings, Eric. Predicting Alloreactivity in Transplantation. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040778